Protein: ACTN1
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)

Gene: ACTN1
Organism: Mus musculus
Interactions: 40
UniProt ID: Q7TPR4

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0001726 - ruffle
GO:0003713 - transcription coactivator activity
GO:0003725 - double-stranded RNA binding
GO:0005178 - integrin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1201602

PRAG1
Inactive tyrosine-protein kinase PRAG1

1

5

High-throughput

0.618

High

1274482

PDLI5
PDZ and LIM domain protein 5

1

14

Small-scale

0.618

High

1247096

NEB2
Neurabin-2

2

20

High-throughput

0.584

High

504802

PTPRQ
Phosphatidylinositol phosphatase PTPRQ

1

12

Small-scale

0.553

High

1274479

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

4

High-throughput

0.553

High

1190158

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

4

High-throughput

0.536

High

1190854

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.501

High

1190960

GRM5
Metabotropic glutamate receptor 5

1

2

Small-scale

0.481

High

108731

G3X9H5
Huntingtin

1

3

High-throughput

0.479

High

486825

CADH1
Cadherin-1

1

4

Small-scale

0.479

High

896027

VATA
V-type proton ATPase catalytic subunit A

1

1

Small-scale

0.479

High

999851

TRAF6
TNF receptor-associated factor 6

1

13

Small-scale

0.479

High

1021590

RGS14
Regulator of G-protein signaling 14

1

5

High-throughput

0.479

High

1221703

SC6A4
Sodium-dependent serotonin transporter

1

2

High-throughput

0.479

High

1274485

EED
Polycomb protein EED

1

4

High-throughput

0.479

High

415158

ACHA
Acetylcholine receptor subunit alpha

1

0

Small-scale

0.458

High

509129

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

3

High-throughput

0.457

High

1274490

ANKR1
Ankyrin repeat domain-containing protein 1

1

20

Small-scale

0.457

High

905885

CAV3
Caveolin-3

1

7

High-throughput

0.445

High

1193791

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.445

High

1274483

DNM1L
Dynamin-1-like protein

1

6

High-throughput

0.445

High

1274487

HOME3
Homer protein homolog 3

1

18

High-throughput

0.445

High

1274488

PARK7
Parkinson disease protein 7 homolog

1

1

High-throughput

0.445

High

1274491

TSC1
Hamartin

1

20

High-throughput

0.445

High

1274492

SRCN1
SRC kinase signaling inhibitor 1

1

5

High-throughput

0.445

High

1274486

TRI59
Tripartite motif-containing protein 59

1

4

Small-scale

0.439

High

97615

E9PV60
WD repeat and FYVE domain containing 4

1

4

High-throughput

0.437

High

947716

NPHP4
Nephrocystin-4

1

1

High-throughput

0.437

High

1257353

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.437

High

1274476

FACD2
Fanconi anemia group D2 protein homolog

1

4

High-throughput

0.437

High

1274477

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

14

High-throughput

0.437

High

1274481

MT21E
Protein-lysine methyltransferase METTL21E

1

2

High-throughput

0.437

High

1274489

HSPB2
Heat shock protein beta-2

1

10

High-throughput

0.437

High

1274484

ALMS1
Centrosome-associated protein ALMS1

1

8

Small-scale

0.417

High

148187

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.407

High

204793

ST2B1
Sulfotransferase 2B1

1

1

Small-scale

0.407

High

1274478

COX15
Heme A synthase COX15

1

1

High-throughput

0.407

High

1274480

RD3
Protein RD3

1

1

Small-scale

0.407

High

554291

PCP2
Purkinje cell protein 2

1

0

Small-scale

0.249

Low

1274493

B9D1
B9 domain-containing protein 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025