Protein: TRAF6
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)

Gene: TRAF6
Organism: Mus musculus
Interactions: 129
UniProt ID: P70196

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0001503 - ossification
GO:0001701 - in utero embryonic development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

999825

TRAF6
TNF receptor-associated factor 6

5

20

Small-scale

0.912

High

957879

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

20

Small-scale

0.861

High

957261

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.776

High

999843

M3K7
Mitogen-activated protein kinase kinase kinase 7

10

18

Small-scale

0.750

High

648043

MYD88
Myeloid differentiation primary response protein MyD88

8

19

Small-scale

0.746

High

999845

IRAK1
Interleukin-1 receptor-associated kinase 1

8

12

Small-scale

0.746

High

999904

BAG6
Large proline-rich protein BAG6

2

12

Small-scale

0.743

High

999865

ITCH
E3 ubiquitin-protein ligase Itchy

4

20

Small-scale

0.694

High

204647

TNR11
Tumor necrosis factor receptor superfamily member 11A

4

20

Small-scale

0.681

High

693159

TNR5
Tumor necrosis factor receptor superfamily member 5

4

20

Small-scale

0.681

High

312481

NEMO
NF-kappa-B essential modulator

4

19

Small-scale

0.680

High

999856

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.665

High

999838

TNAP3
Tumor necrosis factor alpha-induced protein 3

3

20

Small-scale

0.662

High

999898

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

3

3

Small-scale

0.658

High

999852

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

3

11

Small-scale

0.657

High

999826

IRF7
Interferon regulatory factor 7

3

20

Small-scale

0.656

High

999835

TAXB1
Tax1-binding protein 1 homolog

3

20

Small-scale

0.650

High

999842

M3K3
Mitogen-activated protein kinase kinase kinase 3

3

18

Small-scale

0.650

High

999846

SQSTM
Sequestosome-1

3

15

Small-scale

0.650

High

999895

TLR4
Toll-like receptor 4

3

11

Small-scale

0.650

High

999872

IRAK3
Interleukin-1 receptor-associated kinase 3

3

12

Small-scale

0.629

High

999873

CIKS
E3 ubiquitin ligase TRAF3IP2

3

12

Small-scale

0.629

High

999879

ARRB2
Beta-arrestin-2

2

3

Small-scale

0.624

High

999844

NR0B2
Nuclear receptor subfamily 0 group B member 2

2

6

Small-scale

0.621

High

999897

RNF11
RING finger protein 11

2

7

Small-scale

0.621

High

999839

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.618

High

999853

TCAM1
TIR domain-containing adapter molecule 1

2

12

Small-scale

0.611

High

999833

TRAD1
TRAF-type zinc finger domain-containing protein 1

2

10

Small-scale

0.608

High

999901

CHIP
E3 ubiquitin-protein ligase CHIP

2

13

Small-scale

0.601

High

728516

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.584

High

940796

IRF5
Interferon regulatory factor 5

2

20

Small-scale

0.584

High

944133

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

2

20

Small-scale

0.584

High

999883

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

2

18

Small-scale

0.584

High

999884

TLR3
Toll-like receptor 3

2

11

Small-scale

0.584

High

988876

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

Small-scale

0.578

High

999869

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

Small-scale

0.575

High

999850

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

7

Small-scale

0.573

High

478506

ITB1
Integrin beta-1

1

5

Small-scale

0.561

High

616116

KS6A3
Ribosomal protein S6 kinase alpha-3

1

13

Small-scale

0.561

High

999847

MYSM1
Deubiquitinase MYSM1

1

10

Small-scale

0.561

High

999858

ARRB1
Beta-arrestin-1

1

3

Small-scale

0.561

High

999834

NTRK1
High affinity nerve growth factor receptor

1

12

Small-scale

0.554

High

999832

NLRX1
NLR family member X1

2

20

Small-scale

0.549

High

999854

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.537

High

266982

FHL2
Four and a half LIM domains protein 2

1

19

Small-scale

0.515

High

946712

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.515

High

999831

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

7

Small-scale

0.515

High

999866

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

1

Small-scale

0.515

High

999880

NRIF1
Neurotrophin receptor-interacting factor 1

1

20

Small-scale

0.515

High

999896

LIMD1
LIM domain-containing protein 1

1

19

Small-scale

0.515

High

999890

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

9

Small-scale

0.489

High

609016

HS71B
Heat shock 70 kDa protein 1B

1

20

Small-scale

0.488

High

999862

Q8C0E5
E3 ubiquitin ligase TRAF3IP2

1

12

Small-scale

0.483

High

107139

F8VQ72
Mitogen-activated protein kinase kinase kinase 1

1

19

Small-scale

0.479

High

204501

TNF11
Tumor necrosis factor ligand superfamily member 11

1

9

Small-scale

0.479

High

312654

BECN1
Beclin-1

1

3

Small-scale

0.479

High

313444

CASP8
Caspase-8

1

20

Small-scale

0.479

High

421221

ALDOA
Fructose-bisphosphate aldolase A

1

4

Small-scale

0.479

High

431335

SRC
Proto-oncogene tyrosine-protein kinase Src

1

14

Small-scale

0.479

High

462110

HS90A
Heat shock protein HSP 90-alpha

1

15

Small-scale

0.479

High

518670

EF1A1
Elongation factor 1-alpha 1

1

9

Small-scale

0.479

High

547246

HS90B
Heat shock protein HSP 90-beta

1

16

Small-scale

0.479

High

599240

IL7RA
Interleukin-7 receptor subunit alpha

1

1

Small-scale

0.479

High

602287

HSP72
Heat shock-related 70 kDa protein 2

1

20

Small-scale

0.479

High

602917

ENOA
Alpha-enolase

1

4

Small-scale

0.479

High

627464

BIP
Endoplasmic reticulum chaperone BiP

1

20

Small-scale

0.479

High

651510

CBL
E3 ubiquitin-protein ligase CBL

1

18

Small-scale

0.479

High

660947

IRF8
Interferon regulatory factor 8

1

20

Small-scale

0.479

High

704493

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.479

High

762691

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

20

Small-scale

0.479

High

767003

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

8

Small-scale

0.479

High

869537

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

896003

VATA
V-type proton ATPase catalytic subunit A

1

6

Small-scale

0.479

High

912287

KPYM
Pyruvate kinase PKM

1

9

Small-scale

0.479

High

945613

ACTN4
Alpha-actinin-4

1

14

Small-scale

0.479

High

945958

EF2
Elongation factor 2

1

5

Small-scale

0.479

High

953232

ACTB
Actin, cytoplasmic 1

1

20

Small-scale

0.479

High

989235

HSP7C
Heat shock cognate 71 kDa protein

1

20

Small-scale

0.479

High

999829

SMN
Survival motor neuron protein

1

2

Small-scale

0.479

High

999830

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.479

High

999836

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

14

Small-scale

0.479

High

999837

ZC12A
Endoribonuclease ZC3H12A

1

6

Small-scale

0.479

High

999840

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.479

High

999841

I17RA
Interleukin-17 receptor A

1

5

Small-scale

0.479

High

999848

MABP1
Mitogen-activated protein kinase-binding protein 1

1

7

Small-scale

0.479

High

999849

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

Small-scale

0.479

High

999851

ACTN1
Alpha-actinin-1

1

13

Small-scale

0.479

High

999857

TCAM2
TIR domain-containing adapter molecule 2

1

11

Small-scale

0.479

High

999859

TNR27
Tumor necrosis factor receptor superfamily member 27

1

10

Small-scale

0.479

High

999860

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

20

Small-scale

0.479

High

999861

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

20

Small-scale

0.479

High

999863

Q8C253
Galectin

1

12

Small-scale

0.479

High

999864

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

20

Small-scale

0.479

High

999867

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

Small-scale

0.479

High

999868

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

12

Small-scale

0.479

High

999870

WDR24
GATOR2 complex protein WDR24

1

20

Small-scale

0.479

High

999871

CAR11
Caspase recruitment domain-containing protein 11

1

17

Small-scale

0.479

High

999874

TRI29
Tripartite motif-containing protein 29

1

20

Small-scale

0.479

High

999875

MAVS
Mitochondrial antiviral-signaling protein

1

17

Small-scale

0.479

High

999877

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

20

Small-scale

0.479

High

999878

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

10

Small-scale

0.479

High

999881

STK26
Serine/threonine-protein kinase 26

1

20

Small-scale

0.479

High

999882

ARP3
Actin-related protein 3

1

20

Small-scale

0.479

High

999885

CUL5
Cullin-5

1

20

Small-scale

0.479

High

999886

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

5

Small-scale

0.479

High

999888

TLR9
Toll-like receptor 9

1

11

Small-scale

0.479

High

999892

PKHO1
Pleckstrin homology domain-containing family O member 1

1

1

Small-scale

0.479

High

999893

TNR19
Tumor necrosis factor receptor superfamily member 19

1

10

Small-scale

0.479

High

999894

MTOR
Serine/threonine-protein kinase mTOR

1

13

Small-scale

0.479

High

999900

VAV3
Guanine nucleotide exchange factor VAV3

1

10

Small-scale

0.479

High

999902

GSK3B
Glycogen synthase kinase-3 beta

1

10

Small-scale

0.479

High

999903

SUFU
Suppressor of fused homolog

1

1

Small-scale

0.479

High

999889

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

20

Small-scale

0.470

High

420088

PRIO
Major prion protein

1

0

Small-scale

0.458

High

605434

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

Small-scale

0.458

High

999827

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

571208

CALR
Calreticulin

1

3

High-throughput

0.457

High

999828

FHL1
Four and a half LIM domains protein 1

1

19

High-throughput

0.457

High

999876

PAXI
Paxillin

1

20

High-throughput

0.457

High

999887

OCAT1
POU domain class 2-associating factor 2

1

0

High-throughput

0.438

High

62344

A4FUW1
Regulatory-associated protein of mTOR

1

12

Small-scale

0.437

High

116909

I7GPR1
E3 ubiquitin ligase TRAF3IP2

1

12

Small-scale

0.437

High

718493

MSRE
Macrophage scavenger receptor types I and II

1

7

Small-scale

0.437

High

801612

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.437

High

940808

ATPB
ATP synthase F(1) complex catalytic subunit beta, mitochondrial

1

9

Small-scale

0.437

High

999891

I17RB
Interleukin-17 receptor B

1

5

Small-scale

0.437

High

999899

DOK3
Docking protein 3

1

4

Small-scale

0.437

High

999855

I17RE
Interleukin-17 receptor E

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025