HitPredict

Interactor 1: UBX (P83949)
Homeotic protein ultrabithorax
Gene: UBX

Interactor 2: AL (Q06453)
Homeobox protein aristaless
Gene: AL

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.876

Property	Details
Experiments	30247122, 16455680, 25286318
Identification Methods	protein complementation assay, two hybrid, pull down, affinity chromatography technology, phage display
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0007480 - imaginal disc-derived leg morphogenesis GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 389 Dm			1 408
+	Dm
		185813 UBX_DROME (1-389): 3.26e-124: 365: 100.00		PAX6_DROME (47-368): 7.56e-35: 138: 25.52
+	Dm
		185927 UBX_DROME (1-389): 3.26e-124: 365: 100.00		PITX_DROME (54-325): 4.76e-35: 137: 25.27
+	Dm
		447432 UBX_DROME (1-389): 3.26e-124: 365: 100.00		GSBN_DROME (30-253): 2.28e-32: 128: 33.04
+	Dm
		950100 UBX_DROME (1-389): 3.26e-124: 365: 100.00		Q9W1H7_DROME (70-186): 1.28e-30: 119: 43.59
+	Dm
		950110 UBX_DROME (1-389): 3.26e-124: 365: 100.00		Q9XZU0_DROME (77-299): 2.16e-29: 118: 33.33
+	Dm
		668243 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		AL_DROME (1-408): 3.74e-52: 181: 100.00
+	Hs
		641345 MNX1_HUMAN (197-387): 6.03e-52: 179: 33.67		PAX6_HUMAN (38-317): 9.32e-38: 143: 26.67
+	Hs
		620134 MNX1_HUMAN (197-387): 6.03e-52: 179: 33.67		PAX7_HUMAN (69-363): 8.07e-30: 122: 23.39
+	Dm
		185806 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		PAX6_DROME (47-368): 7.56e-35: 138: 25.52
+	Dm
		185925 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		PITX_DROME (54-325): 4.76e-35: 137: 25.27
+	Dm
		415559 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		PRD_DROME (8-371): 7.24e-34: 135: 21.77
+	Dm
		447431 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		GSBN_DROME (30-253): 2.28e-32: 128: 33.04
+	Hs
		678782 HXD3_HUMAN (213-387): 2.01e-35: 136: 33.14		ALX4_HUMAN (55-210): 1.21e-39: 148: 40.85
+	Dm
		668312 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		Q9W1H7_DROME (70-186): 1.28e-30: 119: 43.59
+	Dm
		668320 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		Q9XZU0_DROME (77-299): 2.16e-29: 118: 33.33
+	Dm
		48151 ABDA_DROME (260-376): 4.98e-42: 157: 59.32		A0AVV3_DROME (77-146): 1.45e-20: 95.5: 77.14
+	Hs
		960051 HXC5_HUMAN (232-361): 4.8e-36: 132: 39.26		LHX4_HUMAN (86-310): 1.87e-28: 117: 17.33
+	Ce
		447556 HM30_CAEEL (252-378): 2.24e-34: 129: 27.56		MEC3_CAEEL (9-162): 3.32e-28: 114: 22.73
+	Hs
		620236 MEOX2_HUMAN (114-366): 8.49e-34: 129: 20.16		PAX3_HUMAN (59-363): 1.5e-26: 112: 23.28
+	Hs
		882139 GSC_HUMAN (137-378): 1.64e-36: 135: 19.59		ZFHX4_HUMAN (44-181): 5e-09: 60.5: 17.99