HitPredict

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: PIN1 (Q13526)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)
Gene: PIN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.701

The method score is based on:

Property	Details
Experiments	19122240, 21685363, 19920136, 21988832
Identification Methods	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001666 - response to hypoxia GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 5 others more... GO:0008013 - beta-catenin binding GO:0042177 - negative regulation of protein catabolic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050821 - protein stabilization GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	425
Hs

1	163

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024