HitPredict

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: CPSF7 (Q8N684)
Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
Gene: CPSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	25416956, 25910212, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 471
+	Hs
		1078587 SMAD2_HUMAN (1-425): 0: 589: 83.73		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		516464 SMAD3_HUMAN (1-425): 0: 636: 100.00		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		171393 SMAD9_HUMAN (1-425): 0: 559: 58.62		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28