HitPredict

Interactor 1: H4 (P84040)
Histone H4
Gene: His4

Interactor 2: ISWI (Q24368)
Chromatin-remodeling complex ATPase chain Iswi (EC 3.6.4.-) (CHRAC 140 kDa subunit) (Nucleosome-remodeling factor 140 kDa subunit) (NURF-140) (Protein imitation swi)
Gene: ISWI

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28109157
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 103 Dm			1 1027
+	Hs
		229352 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		SMCA5_HUMAN (12-1027): 0: 955: 71.07
+	Sc
		356774 H4_YEAST (18-103): 5.86e-41: 132: 90.70		ISW2_YEAST (2-1027): 0: 828: 45.36
+	Hs
		917182 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD3_HUMAN (13-892): 0: 795: 28.80
+	Hs
		917277 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD4_HUMAN (11-1011): 0: 794: 25.85
+	Sc
		356424 H4_YEAST (18-103): 5.86e-41: 132: 90.70		ISW1_YEAST (2-1018): 0: 799: 43.57
+	Hs
		151483 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD2_HUMAN (58-1026): 0: 716: 29.24
+	Sp
		144535 H4_SCHPO (18-103): 4.71e-42: 135: 89.54		HRP3_SCHPO (1-1027): 0: 714: 28.26
+	Sc
		356350 H4_YEAST (18-103): 5.86e-41: 132: 90.70		CHD1_YEAST (3-1020): 0: 717: 27.01
+	Sc
		356248 H4_YEAST (18-103): 5.86e-41: 132: 90.70		SNF2_YEAST (7-721): 0: 685: 36.79
+	Hs
		846914 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		SMCA4_HUMAN (64-602): 5.06e-129: 430: 43.81
+	Hs
		917533 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD1L_HUMAN (128-694): 3.27e-132: 423: 42.38
+	Sc
		356344 H4_YEAST (18-103): 5.86e-41: 132: 90.70		STH1_YEAST (9-659): 2e-129: 427: 41.31
+	Hs
		918062 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD7_HUMAN (669-1027): 1.35e-21: 104: 12.53
+	Hs
		917635 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD6_HUMAN (642-949): 2.18e-14: 80.3: 9.91
+	Hs
		917364 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD9_HUMAN (788-1016): 4.02e-13: 76.4: 15.85
+	Hs
		917965 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CHD8_HUMAN (668-1019): 5.03e-11: 69.5: 12.86