HitPredict

Interactor 1: H4 (P84040)
Histone H4
Gene: His4

Interactor 2: CID (Q9V6Q2)
Histone H3-like centromeric protein cid (CENP-A homolog) (Centromere identifier protein)
Gene: CID

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	32134144, 16775420, 26586808, 24469636, 17676993, 16601098
Identification Methods	x-ray crystallography, pull down, affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 103 Dm			1 225
+	Hs
		917093 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		H31_HUMAN (91-221): 7.69e-57: 178: 31.34
+	Mm
		918236 H4_MOUSE (1-103): 1.72e-48: 151: 99.03		H31_MOUSE (91-221): 7.69e-57: 178: 31.34
+	Hs
		917112 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		H33_HUMAN (91-221): 1.58e-55: 175: 30.60
+	Hs
		917352 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		H31T_HUMAN (91-221): 1.11e-55: 175: 29.85
+	Mm
		918240 H4_MOUSE (1-103): 1.72e-48: 151: 99.03		H33_MOUSE (91-221): 1.58e-55: 175: 30.60
+	Xl
		917054 H4_XENLA (1-103): 1.72e-48: 151: 99.03		H32_XENLA (91-221): 2.49e-55: 174: 30.60
+	Xl
		917056 H4_XENLA (1-103): 1.72e-48: 151: 99.03		Q92133_XENLA (91-221): 2.66e-55: 174: 30.60
+	Hs
		917448 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		H3C_HUMAN (91-221): 3.86e-55: 174: 31.58
+	Hs
		917483 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Mm
		918239 H4_MOUSE (1-103): 1.72e-48: 151: 99.03		H32_MOUSE (91-221): 2.49e-55: 174: 30.60
+	Ce
		445733 H4_CAEEL (1-103): 1.22e-48: 151: 98.06		H3_CAEEL (91-221): 6.03e-55: 173: 29.85
+	Ce
		711990 H4_CAEEL (1-103): 1.22e-48: 151: 98.06		HCP3L_CAEEL (50-219): 1.64e-51: 169: 24.08
+	Sp
		448920 H4_SCHPO (18-103): 4.71e-42: 135: 89.54		H31_SCHPO (91-221): 5.8e-53: 168: 30.60
+	Hs
		828186 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		CENPA_HUMAN (96-220): 1.01e-45: 150: 34.35
+	Hs
		1174638 H4G_HUMAN (1-98): 1.39e-38: 126: 83.67		H32_HUMAN (91-221): 2.49e-55: 174: 30.60
+	Sc
		356652 H4_YEAST (18-103): 5.86e-41: 132: 90.70		H3_YEAST (91-221): 1.86e-49: 159: 30.60
+	Sc
		356401 H4_YEAST (18-103): 5.86e-41: 132: 90.70		CENPA_YEAST (115-218): 1.39e-22: 93.3: 34.29
+	Kl
		1150023 Q6CMU6_KLULA (18-103): 9.09e-42: 134: 91.86		CENPA_KLULA (133-218): 1.74e-21: 89.5: 36.78