HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: SPT2 (Q68D10)
Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1)
Gene: SPTY2D1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SPT2
Common GO terms	GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 685
+	Hs
		934873 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		SPT2_HUMAN (1-664): 1.28e-103: 332: 100.00
+	Hs
		935324 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CHD7_HUMAN (123-489): 2.89e-20: 98.7: 11.25
+	Hs
		952670 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		CHD7_HUMAN (123-489): 2.89e-20: 98.7: 11.25
+	Hs
		935066 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CBP_HUMAN (105-562): 5.99e-14: 77.9: 15.12
+	Hs
		1086253 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		CBP_HUMAN (105-562): 5.99e-14: 77.9: 15.12
+	Mm
		101827 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		F8WI37_MOUSE (149-584): 1.68e-09: 63.6: 8.76
+	Hs
		935004 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		KMT2C_HUMAN (87-564): 4.23e-09: 62.4: 11.37
+	Hs
		828410 CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76		CHD7_HUMAN (123-489): 2.89e-20: 98.7: 11.25
+	Hs
		952479 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		KMT2C_HUMAN (87-564): 4.23e-09: 62.4: 11.37
+	Hs
		1086228 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		KMT2C_HUMAN (87-564): 4.23e-09: 62.4: 11.37
+	Hs
		1174600 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		KMT2C_HUMAN (87-564): 4.23e-09: 62.4: 11.37
+	Sc
		730797 CENPA_YEAST (18-134): 3.39e-40: 135: 56.67		SEC31_YEAST (141-621): 4.05e-21: 100: 13.23