HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: AFF4 (Q9UHB7)
AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)
Gene: AFF4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36089195
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0007286 - spermatid development
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 1163
+	Hs
		935344 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		AFF4_HUMAN (1-1163): 1.3e-124: 413: 100.00
+	Hs
		850811 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		AFF1_HUMAN (4-1160): 4.79e-88: 312: 34.47
+	Hs
		934763 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		MDC1_HUMAN (67-908): 1.82e-35: 149: 9.85
+	Hs
		952338 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		MDC1_HUMAN (67-908): 1.82e-35: 149: 9.85
+	Mm
		952750 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		ATRX_MOUSE (45-862): 1.63e-31: 136: 12.95
+	Hs
		935324 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		CHD7_HUMAN (73-891): 6.5e-25: 115: 12.85
+	Hs
		952670 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		CHD7_HUMAN (73-891): 6.5e-25: 115: 12.85
+	Hs
		934881 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		NIPBL_HUMAN (91-887): 9.3e-18: 91.6: 16.10
+	Hs
		952407 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		NIPBL_HUMAN (91-887): 9.3e-18: 91.6: 16.10
+	Hs
		828410 CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76		CHD7_HUMAN (73-891): 6.5e-25: 115: 12.85
+	Hs
		934668 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		ANK2_HUMAN (263-904): 2.21e-13: 77.4: 13.44
+	Hs
		965127 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		ANK2_HUMAN (263-904): 2.21e-13: 77.4: 13.44
+	Hs
		935004 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		KMT2C_HUMAN (263-920): 1.07e-09: 65.4: 9.56
+	Hs
		952479 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		KMT2C_HUMAN (263-920): 1.07e-09: 65.4: 9.56
+	Hs
		1086228 H31T_HUMAN (1-136): 2.58e-59: 181: 93.38		KMT2C_HUMAN (263-920): 1.07e-09: 65.4: 9.56
+	Mm
		101827 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		F8WI37_MOUSE (181-1062): 2.36e-09: 64.3: 7.98
+	Hs
		1174600 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		KMT2C_HUMAN (263-920): 1.07e-09: 65.4: 9.56
+	Hs
		828271 CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76		NIPBL_HUMAN (91-887): 9.3e-18: 91.6: 16.10