HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: DNM3A (Q9Y6K1)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)
Gene: DNMT3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	36089195, 19834512
Identification Methods	proximity labelling technology, nuclear magnetic resonance, isothermal titration calorimetry, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 912
+	Hs
		935442 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		DNM3A_HUMAN (1-912): 0: 1626: 100.00
+	Mm
		291727 H33_MOUSE (1-136): 1.12e-59: 182: 100.00		DNM3A_MOUSE (4-912): 0: 1618: 96.26
+	Hs
		828439 CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76		DNM3A_HUMAN (1-912): 0: 1626: 100.00
+	Hs
		935328 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		DNM3B_HUMAN (151-911): 0: 1277: 53.07
+	Hs
		952687 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		DNM3L_HUMAN (476-815): 1.32e-179: 525: 40.18
+	Hs
		1174681 H32_HUMAN (1-136): 5.32e-59: 180: 97.06		DNM3L_HUMAN (476-815): 1.32e-179: 525: 40.18
+	Hs
		935132 H31_HUMAN (1-136): 3.08e-60: 183: 96.32		PWP2A_HUMAN (286-377): 1.77e-27: 121: 31.58
+	Hs
		952557 H33_HUMAN (1-136): 1.12e-59: 182: 100.00		PWP2A_HUMAN (286-377): 1.77e-27: 121: 31.58