HitPredict

Interactor 1: RHG08 (P85298)
Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8)
Gene: ARHGAP8

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 464 Hs			1 347
+	Hs
		952919 RHG08_HUMAN (1-464): 3.54e-162: 468: 100.00		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		69705 B1AHC3_HUMAN (1-464): 4.62e-152: 445: 93.32		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		952918 RHG08_HUMAN (1-464): 3.54e-162: 468: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		69704 B1AHC3_HUMAN (1-464): 4.62e-152: 445: 93.32		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		81935 B7ZMA4_HUMAN (1-464): 7.04e-147: 429: 89.61		SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00
+	Hs
		69703 B1AHC3_HUMAN (1-464): 4.62e-152: 445: 93.32		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		81934 B7ZMA4_HUMAN (1-464): 7.04e-147: 429: 89.61		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		1224597 Q8IZM6_HUMAN (1-464): 3.6e-151: 438: 93.10		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		81933 B7ZMA4_HUMAN (1-464): 7.04e-147: 429: 89.61		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		993058 RHG01_HUMAN (8-419): 5.34e-124: 369: 52.54		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		69699 B1AHC3_HUMAN (1-464): 4.62e-152: 445: 93.32		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		200232 SRGP3_HUMAN (81-461): 2.82e-70: 243: 19.06		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		81928 B7ZMA4_HUMAN (1-464): 7.04e-147: 429: 89.61		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		200231 SRGP3_HUMAN (81-461): 2.82e-70: 243: 19.06		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Ce
		70015 C5NU64_CAEEL (55-444): 3.42e-77: 255: 20.96		SH3GH_CAEEL (1-345): 1.27e-65: 213: 42.93
+	Hs
		1052250 RHG24_HUMAN (216-452): 1.74e-68: 233: 25.81		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		200212 SRGP3_HUMAN (81-461): 2.82e-70: 243: 19.06		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		924686 RHG12_HUMAN (178-412): 3.49e-69: 237: 23.53		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		64687 RHG32_HUMAN (149-449): 1.15e-67: 236: 20.62		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		924608 Q1RLN5_HUMAN (159-412): 2.37e-68: 234: 22.18		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38