HitPredict

Interactor 1: POP1 (P87060)
WD repeat-containing protein pop1 (WD repeat-containing protein ste16)
Gene: POP1

Interactor 2: SKP1 (Q9Y709)
Suppressor of kinetochore protein 1 (P19/Skp1 homolog)
Gene: SKP1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	15147268, 12167173
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005634 - nucleus GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0043224 - nuclear SCF ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 775 Sp			1 161
+	Sp
		144900 POP2_SCHPO (71-774): 2.13e-120: 379: 31.29		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Mm
		1257397 FBXW7_MOUSE (539-774): 5.29e-61: 220: 27.39		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Hs
		929021 FBXW7_HUMAN (472-767): 8.18e-61: 219: 24.50		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Ce
		105479 SEL10_CAEEL (556-766): 4.23e-56: 204: 26.03		SKR1_CAEEL (3-160): 1.7e-78: 232: 56.10
+	Sp
		953229 POF1_SCHPO (603-770): 6.7e-37: 149: 25.57		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Hs
		929125 FBW1A_HUMAN (617-774): 5.45e-36: 146: 23.49		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Xl
		1174984 TRCB_XENLA (617-774): 4.97e-36: 145: 23.49		SKP1_XENLA (1-161): 9e-82: 240: 55.76
+	Mm
		1112932 FBW1A_MOUSE (617-774): 5.53e-35: 143: 22.89		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Dm
		218244 O44382_DROME (617-774): 5.48e-36: 144: 23.49		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Dm
		285012 Q9VDE3_DROME (617-774): 8.19e-36: 144: 23.49		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Dm
		1180601 Q9VDE3_DROME (617-774): 8.19e-36: 144: 23.49		Q7KJ69_DROME (1-161): 4.35e-74: 220: 53.37
+	Ce
		105997 LIN23_CAEEL (617-773): 9.67e-34: 140: 23.03		G5EDD8_CAEEL (3-160): 3.13e-67: 203: 46.34
+	Dm
		1363661 Q9VDE3_DROME (617-774): 8.19e-36: 144: 23.49		Q9VWC4_DROME (2-151): 2.3e-65: 198: 47.71
+	Hs
		929116 FBXW2_HUMAN (613-764): 2.41e-21: 99.8: 15.39		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Mm
		1351515 Q9QUH1_MOUSE (613-764): 9.42e-21: 97.9: 14.74		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Sp
		1000009 POF11_SCHPO (315-525): 8.53e-21: 98.6: 17.76		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Sc
		759309 MET30_YEAST (289-537): 2.11e-26: 117: 11.37		SKP1_YEAST (2-161): 5.56e-66: 201: 50.00
+	Mm
		1131317 FBW1B_MOUSE (686-767): 5.69e-11: 67.7: 14.46		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Dm
		285042 FBXW7_DROME (688-766): 3.73e-13: 75.5: 16.05		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Sc
		431143 CDC4_YEAST (696-773): 1.88e-10: 66.6: 13.10		SKP1_YEAST (2-161): 5.56e-66: 201: 50.00