HitPredict

Interactor 1: SMAD4 (P97471)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
Gene: SMAD4

Interactor 2: Q8BTS0 (Q8BTS0)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5)
Gene: Ddx5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15464984
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0030509 - BMP signaling pathway GO:0070412 - R-SMAD binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 551 Mm			1 615
+	Mm
		936615 SMAD1_MOUSE (20-545): 0: 552: 34.41		Q8BTS0_MOUSE (1-615): 0: 614: 100.00
+	Hs
		571470 SMAD1_HUMAN (20-545): 0: 554: 34.59		DDX5_HUMAN (1-615): 0: 609: 98.86
+	Hs
		571568 SMAD5_HUMAN (20-545): 0: 540: 34.03		DDX5_HUMAN (1-615): 0: 609: 98.86
+	Mm
		1207259 SMAD3_MOUSE (19-548): 1.83e-171: 493: 31.65		Q8BTS0_MOUSE (1-615): 0: 614: 100.00
+	Hs
		571401 SMAD3_HUMAN (19-548): 1.83e-171: 493: 31.65		DDX5_HUMAN (1-615): 0: 609: 98.86
+	Mm
		1143947 SMAD2_MOUSE (19-548): 2.61e-163: 474: 28.89		Q8BTS0_MOUSE (1-615): 0: 614: 100.00
+	Hs
		133977 SMAD3_HUMAN (19-548): 1.83e-171: 493: 31.65		DDX3X_HUMAN (3-478): 1.97e-148: 445: 38.66
+	Hs
		181693 SMAD3_HUMAN (19-548): 1.83e-171: 493: 31.65		DDX3Y_HUMAN (3-485): 3.4e-148: 445: 37.40
+	Hs
		181701 SMAD2_HUMAN (19-548): 2.08e-162: 472: 28.89		DDX3Y_HUMAN (3-485): 3.4e-148: 445: 37.40
+	Mm
		192488 SMAD7_MOUSE (37-181): 6.43e-33: 132: 20.59		Q8BTS0_MOUSE (1-615): 0: 614: 100.00