HitPredict

Interactor 1: RPB3 (P97760)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)
Gene: Polr2c

Interactor 2: Q3TYI2 (Q3TYI2)
DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein
Gene: Polr2j

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	20211142
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RNA_pol_L~RNA_pol_L_2
Common GO terms	GO:0001055 - RNA polymerase II activity GO:0003677 - DNA binding GO:0005665 - RNA polymerase II, core complex GO:0046983 - protein dimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 275 Mm			1 117
+	Hs
		583438 RPB3_HUMAN (1-275): 7.69e-138: 391: 99.27		RPB11_HUMAN (1-117): 3.43e-53: 164: 99.15
+	Hs
		583571 RPB3_HUMAN (1-275): 7.69e-138: 391: 99.27		RPB1B_HUMAN (1-109): 1.39e-47: 149: 94.50
+	Dm
		333012 O97183_DROME (1-274): 2.87e-129: 369: 68.36		RPB11_DROME (1-115): 3.24e-49: 154: 77.39
+	Hs
		169818 RPAC1_HUMAN (3-269): 1.26e-110: 324: 26.23		RPB11_HUMAN (1-117): 3.43e-53: 164: 99.15
+	Hs
		169946 RPAC1_HUMAN (3-269): 1.26e-110: 324: 26.23		RPB1C_HUMAN (1-109): 1.16e-48: 152: 95.41
+	Hs
		169941 RPAC1_HUMAN (3-269): 1.26e-110: 324: 26.23		RPB1B_HUMAN (1-109): 1.39e-47: 149: 94.50
+	Sc
		558050 RPB3_YEAST (4-271): 7.65e-107: 314: 45.06		RPB11_YEAST (1-110): 7.1e-45: 143: 49.09
+	Hs
		169778 RPAC1_HUMAN (3-269): 1.26e-110: 324: 26.23		RPAC2_HUMAN (12-116): 1.08e-39: 130: 30.56
+	At
		1104914 NRPB3_ARATH (3-272): 1.33e-101: 300: 39.22		NRPBB_ARATH (1-115): 7.88e-49: 153: 46.09
+	At
		1104915 RPD3B_ARATH (3-272): 1.37e-99: 295: 38.03		NRPBB_ARATH (1-115): 7.88e-49: 153: 46.09
+	Sc
		557923 RPB3_YEAST (4-271): 7.65e-107: 314: 45.06		RPAC2_YEAST (13-110): 1e-32: 113: 33.33
+	Sp
		741615 RPB3_SCHPO (8-275): 8.55e-100: 295: 43.73		RPB11_SCHPO (1-117): 5.03e-40: 131: 44.44
+	Sp
		293857 RPAC1_SCHPO (3-269): 1.61e-99: 296: 22.80		RPAC2_SCHPO (15-109): 8.5e-37: 122: 34.74
+	Dm
		1368240 Q9VMX3_DROME (3-266): 4.87e-102: 302: 26.76		RPAC2_DROME (32-116): 2.98e-29: 103: 28.24
+	Sc
		429651 RPAC1_YEAST (3-261): 1.14e-96: 288: 25.42		RPAC2_YEAST (13-110): 1e-32: 113: 33.33
+	Ss
		955989 RPO3_SACS2 (8-263): 3.08e-77: 236: 27.01		RPO11_SACS2 (19-106): 1.87e-25: 93.2: 31.82
+	Mj
		1123053 RPO3_METJA (9-268): 1.15e-62: 197: 27.00		RPO11_METJA (19-108): 2.04e-19: 78.2: 23.47