Protein: MITF
Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)

Gene: MITF
Organism: Homo sapiens
Interactions: 52
UniProt ID: O75030

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

269090

TFEB
Transcription factor EB

4

13

Small-scale

0.903

High

269091

TFE3
Transcription factor E3

4

13

Small-scale

0.895

High

269111

FHL2
Four and a half LIM domains protein 2

1

6

High-throughput

0.691

High

269122

LEF1
Lymphoid enhancer-binding factor 1

3

10

Small-scale

0.682

High

269092

PAX6
Paired box protein Pax-6

1

2

Small-scale

0.647

High

269103

SUMO1
Small ubiquitin-related modifier 1

3

4

Small-scale

0.640

High

269128

PIAS3
E3 SUMO-protein ligase PIAS3

2

6

Small-scale

0.636

High

269105

RBM6
RNA-binding protein 6

2

1

High-throughput

0.628

High

168931

TFEC
Transcription factor EC

1

13

Small-scale

0.618

High

269088

HXB4
Homeobox protein Hox-B4

1

3

Small-scale

0.618

High

269114

RRAGA
Ras-related GTP-binding protein A

1

9

Small-scale

0.618

High

269115

RPTOR
Regulatory-associated protein of mTOR

1

11

Small-scale

0.618

High

269118

EPAS1
Endothelial PAS domain-containing protein 1

1

19

Small-scale

0.618

High

269120

RRAGC
Ras-related GTP-binding protein C

1

9

Small-scale

0.618

High

269104

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.614

High

269095

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

269100

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

269107

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

269119

CLK4
Dual specificity protein kinase CLK4

1

5

Small-scale

0.578

High

269123

FBW1B
F-box/WD repeat-containing protein 11

1

13

Small-scale

0.561

High

137878

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

Small-scale

0.552

High

269121

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

0

Small-scale

0.549

High

269099

HXK3
Hexokinase-3

1

1

High-throughput

0.541

High

269124

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.541

High

269098

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

Small-scale

0.529

High

269125

FBW1A
F-box/WD repeat-containing protein 1A

1

13

Small-scale

0.527

High

269084

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

269126

KLH20
Kelch-like protein 20

1

0

High-throughput

0.513

High

269080

PIAS1
E3 SUMO-protein ligase PIAS1

1

6

Small-scale

0.501

High

269081

PIAS2
E3 SUMO-protein ligase PIAS2

1

6

Small-scale

0.501

High

269083

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

269089

SPI1
Transcription factor PU.1

1

3

Small-scale

0.501

High

269106

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.501

High

269127

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

269093

MARK3
MAP/microtubule affinity-regulating kinase 3

1

1

Small-scale

0.481

High

172320

XPO1
Exportin-1

1

7

High-throughput

0.479

High

269082

FOS
Protein c-Fos

1

15

Small-scale

0.479

High

269085

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

Small-scale

0.479

High

269086

EGR2
E3 SUMO-protein ligase EGR2

1

2

High-throughput

0.479

High

269087

ERG
Transcriptional regulator ERG

1

2

High-throughput

0.479

High

269094

PML
Protein PML

1

5

High-throughput

0.479

High

269096

CTNB1
Catenin beta-1

1

2

Small-scale

0.479

High

269097

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.479

High

269101

H4
Histone H4

1

11

High-throughput

0.479

High

269108

SUH
Recombining binding protein suppressor of hairless

1

1

Small-scale

0.479

High

269109

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

269113

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

269116

SP7
Transcription factor Sp7

1

12

High-throughput

0.479

High

269117

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

2

Small-scale

0.479

High

269110

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

269102

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.445

High

269112

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025