HitPredict

Interactor 1: CASP7 (P97864)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Interactor 2: XIAP (Q60989)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11859414
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0042742 - defense response to bacterium GO:0051402 - neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Mm			1 496
+	Hs
		876939 CASP7_HUMAN (1-303): 5.55e-143: 406: 82.18		XIAP_HUMAN (1-496): 0: 581: 89.14
+	Hs
		788182 CASP3_HUMAN (57-301): 3.83e-113: 329: 58.78		XIAP_HUMAN (1-496): 0: 581: 89.14
+	Mm
		936913 CASP3_MOUSE (57-301): 2.53e-112: 327: 57.14		XIAP_MOUSE (1-496): 0: 581: 100.00
+	Hs
		957707 CASP8_HUMAN (9-301): 5.02e-104: 313: 36.04		XIAP_HUMAN (1-496): 0: 581: 89.14
+	Hs
		876960 CASP7_HUMAN (1-303): 5.55e-143: 406: 82.18		BIRC7_HUMAN (14-155): 2.21e-33: 130: 23.78
+	Hs
		876964 CASP7_HUMAN (1-303): 5.55e-143: 406: 82.18		BIRC6_HUMAN (252-437): 1.81e-29: 125: 18.69
+	Hs
		876944 CASP7_HUMAN (1-303): 5.55e-143: 406: 82.18		BIRC3_HUMAN (398-496): 4.2e-24: 107: 41.41
+	Hs
		876945 CASP7_HUMAN (1-303): 5.55e-143: 406: 82.18		BIRC2_HUMAN (406-496): 9.26e-23: 103: 40.66
+	Hs
		177663 CASP7_HUMAN (1-303): 5.55e-143: 406: 82.18		BIRC5_HUMAN (265-373): 6.39e-23: 96.5: 28.45
+	Mm
		140026 CASP3_MOUSE (57-301): 2.53e-112: 327: 57.14		BIRC3_MOUSE (150-331): 3.72e-42: 160: 30.18
+	Hs
		788221 CASP3_HUMAN (57-301): 3.83e-113: 329: 58.78		BIRC7_HUMAN (14-155): 2.21e-33: 130: 23.78
+	Hs
		788230 CASP3_HUMAN (57-301): 3.83e-113: 329: 58.78		BIRC6_HUMAN (252-437): 1.81e-29: 125: 18.69
+	Hs
		788193 CASP3_HUMAN (57-301): 3.83e-113: 329: 58.78		BIRC3_HUMAN (398-496): 4.2e-24: 107: 41.41
+	Hs
		788194 CASP3_HUMAN (57-301): 3.83e-113: 329: 58.78		BIRC2_HUMAN (406-496): 9.26e-23: 103: 40.66
+	Hs
		177658 CASP3_HUMAN (57-301): 3.83e-113: 329: 58.78		BIRC5_HUMAN (265-373): 6.39e-23: 96.5: 28.45
+	Hs
		1035745 CASP8_HUMAN (9-301): 5.02e-104: 313: 36.04		BIRC3_HUMAN (398-496): 4.2e-24: 107: 41.41
+	Hs
		1059332 CASP8_HUMAN (9-301): 5.02e-104: 313: 36.04		RFFL_HUMAN (324-496): 9.99e-25: 107: 18.54
+	Hs
		1036271 CASP8_HUMAN (9-301): 5.02e-104: 313: 36.04		BIRC2_HUMAN (406-496): 9.26e-23: 103: 40.66
+	Hs
		1059336 CASP8_HUMAN (9-301): 5.02e-104: 313: 36.04		RNF34_HUMAN (421-496): 2.1e-19: 91.9: 31.58
+	Dm
		137119 CASP1_DROME (19-302): 2.06e-106: 314: 40.69		DIAP1_DROME (240-447): 8.54e-19: 90.8: 16.67