HitPredict

Interactor 1: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Interactor 2: REPS1 (Q96D71)
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Gene: REPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 796
+	Hs
		833640 NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20		REPS1_HUMAN (1-796): 2.33e-108: 351: 100.00
+	Hs
		833668 NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20		EP15R_HUMAN (8-735): 2e-72: 256: 13.93
+	Dm
		91154 NUMB_DROME (24-530): 3.9e-41: 160: 12.25		E3CTP7_DROME (1-695): 1.93e-74: 260: 11.95
+	Hs
		957186 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Hs
		787894 DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Mm
		787999 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		EPS15_MOUSE (4-782): 2.51e-16: 85.8: 10.27
+	Mm
		957157 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		ITSN1_MOUSE (3-100): 1.25e-15: 83.9: 19.39
+	Mm
		957141 DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15		EP15R_MOUSE (4-236): 2.2e-12: 73.1: 12.55
+	Dm
		561284 NUMB_DROME (24-530): 3.9e-41: 160: 12.25		Q8T8W3_DROME (269-370): 7.19e-34: 139: 38.24
+	Ce
		60776 A5JYR4_CAEEL (5-470): 5.67e-37: 147: 22.06		Q8MYM6_CAEEL (255-552): 5.22e-39: 151: 22.54
+	Dm
		112569 NUMB_DROME (24-530): 3.9e-41: 160: 12.25		M9ND00_DROME (1-272): 5.39e-25: 113: 9.23
+	Hs
		787868 NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Mm
		788008 NUMB_MOUSE (22-635): 2.06e-45: 175: 13.54		EPS15_MOUSE (4-782): 2.51e-16: 85.8: 10.27
+	Hs
		269148 DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62		ITSN1_HUMAN (1-115): 1.23e-17: 90.4: 16.52
+	Mm
		1206702 ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67		ITSN1_MOUSE (3-100): 1.25e-15: 83.9: 19.39
+	Ce
		60778 A5JYR4_CAEEL (5-470): 5.67e-37: 147: 22.06		Q8WSP1_CAEEL (4-110): 1.59e-19: 95.4: 15.89
+	Mm
		1141842 ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67		EP15R_MOUSE (4-236): 2.2e-12: 73.1: 12.55
+	Ce
		60780 A5JYR4_CAEEL (5-470): 5.67e-37: 147: 22.06		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41
+	Ce
		283754 CED6_CAEEL (5-428): 1.43e-35: 143: 16.47		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41
+	Ce
		1353620 NUMB1_CAEEL (23-530): 3.63e-34: 140: 11.50		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41