HitPredict

Interactor 1: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: EGFR (Q01279)
Epidermal growth factor receptor (EC 2.7.10.1)
Gene: EGFR

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.873

The method score is based on:

Property Details
Experiments 20676128, 7689150, 7538132, 18174162
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005886 - plasma membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0035556 - intracellular signal transduction
GO:0042127 - regulation of cell population proliferation
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 579
Mm

1 1210
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024