Interactor 1: PKD1 (P98161)
Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)
Gene: PKD1

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 11113628, 27775029
Identification Methods affinity chromatography technology, cosedimentation through density gradient
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_8~PK_Tyr_Ser-Thr
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0019901 - protein kinase binding
GO:0030155 - regulation of cell adhesion
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 4303
Hs

1 1052
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024