HitPredict

Interactor 1: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Interactor 2: SYGP1 (Q96PV0)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: SYNGAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.618

Property	Details
Experiments	36950384, 37207277
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007409 - axonogenesis GO:0043524 - negative regulation of neuron apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 349 Hs			1 1343
+	Hs
		1382428 ISL2_HUMAN (1-349): 4.2e-81: 252: 73.35		SYGP1_HUMAN (1-1343): 0: 1004: 100.00
+	Hs
		1277089 PRIC2_HUMAN (11-336): 6.58e-42: 157: 14.99		SYGP1_HUMAN (1-1343): 0: 1004: 100.00
+	Mm
		104613 ABLM1_MOUSE (2-287): 1.21e-20: 95.1: 14.82		SYGP1_MOUSE (1-1343): 0: 1003: 98.88
+	Mm
		104580 PRIC2_MOUSE (4-69): 3.88e-09: 59.9: 19.12		SYGP1_MOUSE (1-1343): 0: 1003: 98.88
+	Hs
		637869 LIMK2_HUMAN (17-227): 4.95e-68: 226: 25.94		NF1_HUMAN (408-712): 3.22e-82: 301: 23.21
+	Hs
		159167 ABLM1_HUMAN (4-214): 2.65e-21: 97: 14.93		IQGA1_HUMAN (219-857): 5.22e-123: 421: 13.35