Protein: LIMK2
LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)

Gene: LIMK2
Organism: Homo sapiens
Interactions: 91
UniProt ID: P53671

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005801 - cis-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

922238

LIMK1
LIM domain kinase 1

4

18

Small-scale

0.886

High

922313

CDC37
Hsp90 co-chaperone Cdc37

3

13

High-throughput

0.855

High

922306

ROCK1
Rho-associated protein kinase 1

2

9

Small-scale

0.812

High

922305

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

10

High-throughput

0.811

High

468212

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.802

High

461303

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

660005

COF1
Cofilin-1

2

2

Small-scale

0.768

High

549105

CDK4
Cyclin-dependent kinase 4

1

5

High-throughput

0.691

High

573401

ENPL
Endoplasmin

1

20

High-throughput

0.691

High

857389

NOTC1
Neurogenic locus notch homolog protein 1

1

10

High-throughput

0.691

High

916631

PPP5
Serine/threonine-protein phosphatase 5

1

1

High-throughput

0.691

High

922303

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

10

High-throughput

0.691

High

922310

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

High-throughput

0.691

High

922319

ST32C
Serine/threonine-protein kinase 32C

1

10

High-throughput

0.691

High

922346

RPKL1
Ribosomal protein S6 kinase-like 1

1

11

High-throughput

0.691

High

922304

U119A
Protein unc-119 homolog A

4

1

High-throughput

0.683

High

922333

HIPK3
Homeodomain-interacting protein kinase 3

1

18

High-throughput

0.656

High

922323

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

3

1

High-throughput

0.650

High

922296

LIMK2
LIM domain kinase 2

1

17

Small-scale

0.647

High

922331

TTC1
Tetratricopeptide repeat protein 1

4

7

High-throughput

0.630

High

730464

1433S
14-3-3 protein sigma

1

16

High-throughput

0.618

High

922299

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.618

High

922334

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

507122

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

1

High-throughput

0.611

High

922341

TRI35
E3 ubiquitin-protein ligase TRIM35

2

1

High-throughput

0.611

High

258815

DNJA2
DnaJ homolog subfamily A member 2

2

5

High-throughput

0.601

High

922325

PP14B
Protein phosphatase 1 regulatory subunit 14B

2

0

High-throughput

0.595

High

922314

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

922315

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.575

High

922326

AURKB
Aurora kinase B

1

6

High-throughput

0.575

High

922340

DP13A
DCC-interacting protein 13-alpha

1

6

High-throughput

0.575

High

637869

NF1
Neurofibromin

1

14

Small-scale

0.573

High

922297

VMAT1
Chromaffin granule amine transporter

2

4

High-throughput

0.558

High

922322

PARD3
Partitioning defective 3 homolog

1

20

Small-scale

0.553

High

174989

SC16A
Protein transport protein Sec16A

1

7

High-throughput

0.536

High

325748

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

High-throughput

0.536

High

415453

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.536

High

420445

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

High-throughput

0.536

High

483544

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

1

High-throughput

0.536

High

536815

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.536

High

679111

DNJB1
DnaJ homolog subfamily B member 1

1

5

High-throughput

0.536

High

697481

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.536

High

727737

DNJA1
DnaJ homolog subfamily A member 1

1

5

High-throughput

0.536

High

894649

EMD
Emerin

1

2

High-throughput

0.536

High

916212

TXTP
Tricarboxylate transport protein, mitochondrial

1

3

High-throughput

0.536

High

922300

TBA4A
Tubulin alpha-4A chain

1

8

High-throughput

0.536

High

922307

SQSTM
Sequestosome-1

1

3

High-throughput

0.536

High

922317

ECM29
Proteasome adapter and scaffold protein ECM29

1

7

High-throughput

0.536

High

922318

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

2

High-throughput

0.536

High

922324

GCN1
Stalled ribosome sensor GCN1

1

6

High-throughput

0.536

High

922329

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.536

High

922330

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.536

High

922312

KS6A1
Ribosomal protein S6 kinase alpha-1

1

9

Small-scale

0.527

High

138029

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.513

High

214280

MSI1H
RNA-binding protein Musashi homolog 1

1

0

High-throughput

0.513

High

385588

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

565836

EF2
Elongation factor 2

1

0

High-throughput

0.513

High

922342

RUVB2
RuvB-like 2

1

0

High-throughput

0.513

High

388055

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

922302

H11
Histone H1.1

1

3

Small-scale

0.501

High

922344

FBX7
F-box only protein 7

1

5

High-throughput

0.501

High

182497

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

229680

CALU
Calumenin

1

6

High-throughput

0.489

High

829323

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

6

High-throughput

0.489

High

895516

SERPH
Serpin H1

1

1

High-throughput

0.489

High

922309

RCN2
Reticulocalbin-2

1

6

High-throughput

0.489

High

922311

RCN1
Reticulocalbin-1

1

5

High-throughput

0.489

High

922320

SFPA2
Pulmonary surfactant-associated protein A2

1

4

High-throughput

0.489

High

922327

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

1

High-throughput

0.489

High

922335

GHC1
Mitochondrial glutamate carrier 1

1

3

High-throughput

0.489

High

922339

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

2

High-throughput

0.489

High

124758

AIP
AH receptor-interacting protein

1

9

High-throughput

0.479

High

922308

CUL3
Cullin-3

1

1

High-throughput

0.479

High

922332

CECR2
Chromatin remodeling regulator CECR2

1

1

High-throughput

0.479

High

922337

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

922338

XPO7
Exportin-7

1

4

High-throughput

0.479

High

922301

EFNB1
Ephrin-B1

1

20

High-throughput

0.445

High

922336

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.445

High

922345

T22D4
TSC22 domain family protein 4

1

2

High-throughput

0.445

High

391216

FRIL
Ferritin light chain

1

0

High-throughput

0.426

High

922321

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.426

High

124280

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

190337

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

288154

PGRP1
Peptidoglycan recognition protein 1

1

0

High-throughput

0.279

Low

346922

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

894458

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

922316

NU188
Nucleoporin NUP188

1

0

High-throughput

0.279

Low

922343

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.279

Low

922298

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.269

Low

922328

F167A
Protein FAM167A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025