Protein: ISL2
Insulin gene enhancer protein ISL-2 (Islet-2)

Gene: ISL2
Organism: Homo sapiens
Interactions: 44
UniProt ID: Q96A47

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0003677 - DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1379927

LHX4
LIM/homeobox protein Lhx4

6

17

Small-scale

0.947

High

1287918

LDB1
LIM domain-binding protein 1

4

20

High-throughput

0.894

High

1382434

LHX3
LIM/homeobox protein Lhx3

3

18

Small-scale

0.866

High

681891

RBTN2
Rhombotin-2

2

19

High-throughput

0.811

High

965498

LMO4
LIM domain transcription factor LMO4

2

19

High-throughput

0.789

High

1382430

SSBP3
Single-stranded DNA-binding protein 3

5

20

High-throughput

0.718

High

1010768

SSBP2
Single-stranded DNA-binding protein 2

5

20

High-throughput

0.712

High

253022

LMX1B
LIM homeobox transcription factor 1-beta

1

19

High-throughput

0.691

High

682083

RBTN1
Rhombotin-1

1

18

High-throughput

0.691

High

877543

LHX1
LIM/homeobox protein Lhx1

1

17

High-throughput

0.691

High

1040351

DYST
Dystonin

1

1

High-throughput

0.691

High

1347343

LMO3
LIM domain only protein 3

1

19

High-throughput

0.691

High

1382429

SSBP4
Single-stranded DNA-binding protein 4

4

20

High-throughput

0.691

High

961488

ISL1
Insulin gene enhancer protein ISL-1

1

20

Small-scale

0.647

High

1382437

ARI1
E3 ubiquitin-protein ligase ARIH1

2

3

High-throughput

0.628

High

210084

CRX
Cone-rod homeobox protein

1

19

High-throughput

0.618

High

895773

LHX2
LIM/homeobox protein Lhx2

1

17

High-throughput

0.618

High

1229366

LHX8
LIM/homeobox protein Lhx8

1

19

High-throughput

0.618

High

139018

BCL9
B-cell CLL/lymphoma 9 protein

2

20

High-throughput

0.611

High

1382431

IDI2
Isopentenyl-diphosphate delta-isomerase 2

2

2

High-throughput

0.611

High

1382428

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

5

High-throughput

0.601

High

1115883

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.536

High

1214973

RN187
E3 ubiquitin-protein ligase RNF187

1

3

High-throughput

0.536

High

1370278

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

1382432

PICK1
PRKCA-binding protein

1

2

High-throughput

0.536

High

1382436

PYGO1
Pygopus homolog 1

1

20

High-throughput

0.536

High

1134872

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.513

High

1332092

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

1382433

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

1382435

CSN7A
COP9 signalosome complex subunit 7a

1

0

High-throughput

0.513

High

935777

MFAP4
Microfibril-associated glycoprotein 4

1

1

High-throughput

0.489

High

1329571

CA052
UPF0690 protein C1orf52

1

2

High-throughput

0.489

High

143176

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.479

High

474189

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

538452

EGR2
E3 SUMO-protein ligase EGR2

1

10

High-throughput

0.479

High

540926

ERG
Transcriptional regulator ERG

1

6

High-throughput

0.479

High

613133

EGR1
Early growth response protein 1

1

9

High-throughput

0.479

High

872612

SOX2
Transcription factor SOX-2

1

19

High-throughput

0.479

High

887089

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

High-throughput

0.479

High

1087925

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1133588

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1289051

BCL9L
B-cell CLL/lymphoma 9-like protein

1

20

High-throughput

0.479

High

1351116

SP7
Transcription factor Sp7

1

10

High-throughput

0.479

High

1382438

ORC6
Origin recognition complex subunit 6

1

2

High-throughput

0.479

High


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Last updated: 11Aug2025