HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

The method score is based on:

Property	Details
Experiments	25447306, 17234751, 15880652, 12606552, 10640274, 25535359, 15385570, 19696166
Identification Methods	affinity chromatography technology, pull down, enzymatic study, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 8 others more... GO:0010039 - response to iron ion GO:0010468 - regulation of gene expression GO:0010628 - positive regulation of gene expression GO:0019899 - enzyme binding GO:0019904 - protein domain specific binding GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0071456 - cellular response to hypoxia
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	491
Hs

1	826

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024