HitPredict

Interactor 1: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Interactor 2: SREK1 (Q8WXA9)
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)
Gene: SREK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.807

Property	Details
Experiments	11991645, 14559993
Identification Methods	pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0006397 - mRNA processing GO:0008380 - RNA splicing and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 508
+	Hs
		516607 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1263302 SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1031403 PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1263316 PUF60_HUMAN (8-108): 1.34e-23: 100: 23.76		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	At
		790118 PABP2_ARATH (97-202): 2.58e-09: 58.4: 7.55		CID12_ARATH (20-147): 3.84e-22: 99.4: 29.69
+	At
		790115 PABP2_ARATH (97-202): 2.58e-09: 58.4: 7.55		CID8_ARATH (20-152): 8.54e-16: 80.2: 28.36