Protein: COPZ1
Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP)

Gene: COPZ1
Organism: Homo sapiens
Interactions: 176
UniProt ID: P61923

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0006886 - intracellular protein transport
GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

964090

COPG1
Coatomer subunit gamma-1

9

20

Small-scale

0.972

High

921629

COPB
Coatomer subunit beta

6

20

Small-scale

0.946

High

963984

COPZ1
Coatomer subunit zeta-1

3

5

Small-scale

0.827

High

873196

COPD
Coatomer subunit delta

2

3

High-throughput

0.811

High

964078

COPG2
Coatomer subunit gamma-2

2

20

High-throughput

0.811

High

921856

COPA
Coatomer subunit alpha

3

5

Small-scale

0.670

High

158165

COPE
Coatomer subunit epsilon

3

2

High-throughput

0.667

High

888844

TMEDA
Transmembrane emp24 domain-containing protein 10

3

3

Small-scale

0.631

High

773469

COPB2
Coatomer subunit beta'

2

5

High-throughput

0.628

High

612185

ARF4
ADP-ribosylation factor 4

2

11

High-throughput

0.611

High

963991

ARF5
ADP-ribosylation factor 5

2

11

High-throughput

0.611

High

964053

NUDC1
NudC domain-containing protein 1

2

0

High-throughput

0.602

High

964071

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

1

High-throughput

0.601

High

241281

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

395809

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

964042

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

0

Small-scale

0.559

High

297186

PRAF3
PRA1 family protein 3

1

1

High-throughput

0.536

High

328893

RTN3
Reticulon-3

1

2

High-throughput

0.536

High

529500

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

668546

APC
Adenomatous polyposis coli protein

1

2

High-throughput

0.536

High

963995

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.536

High

964000

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

1

High-throughput

0.536

High

964014

ASTRB
Protein Aster-B

1

1

High-throughput

0.536

High

964018

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.536

High

964023

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

1

High-throughput

0.536

High

964026

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.536

High

964037

ATLA2
Atlastin-2

1

3

High-throughput

0.536

High

964048

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.536

High

964049

ASTRA
Protein Aster-A

1

1

High-throughput

0.536

High

964051

SCYL1
N-terminal kinase-like protein

1

2

High-throughput

0.536

High

964082

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.536

High

787960

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

880507

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.513

High

903865

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.513

High

964038

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.513

High

964043

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.513

High

964054

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.513

High

964056

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.513

High

964062

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.513

High

964088

MYO5A
Unconventional myosin-Va

1

0

High-throughput

0.513

High

421850

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

181297

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.489

High

484470

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

932051

EPHA4
Ephrin type-A receptor 4

1

4

High-throughput

0.489

High

963992

RBM10
RNA-binding protein 10

1

2

High-throughput

0.489

High

964009

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.489

High

964035

NAV1
Neuron navigator 1

1

1

High-throughput

0.489

High

172643

XPO1
Exportin-1

1

11

High-throughput

0.479

High

342815

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

345605

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

538933

EPB41
Protein 4.1

1

3

High-throughput

0.479

High

934378

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

963985

ARF6
ADP-ribosylation factor 6

1

11

High-throughput

0.479

High

963986

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

963999

CUL3
Cullin-3

1

1

High-throughput

0.479

High

964019

ATLA3
Atlastin-3

1

3

High-throughput

0.479

High

964024

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

High-throughput

0.479

High

964032

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

964039

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

964065

GLP3L
Golgi phosphoprotein 3-like

1

1

Small-scale

0.479

High

964066

GOLP3
Golgi phosphoprotein 3

1

1

Small-scale

0.479

High

964079

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

964081

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

964085

SHLB1
Endophilin-B1

1

1

High-throughput

0.479

High

347617

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

536887

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

731155

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

830473

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

963993

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.458

High

964011

SEPT7
Septin-7

1

0

High-throughput

0.458

High

964013

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

964046

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

964047

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

964068

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

964074

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

964083

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.458

High

964084

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

477226

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

6

High-throughput

0.457

High

641150

FGFR2
Fibroblast growth factor receptor 2

1

5

High-throughput

0.457

High

710695

EPHA8
Ephrin type-A receptor 8

1

3

High-throughput

0.457

High

777662

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.457

High

48584

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

275505

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

296477

STAM2
Signal transducing adapter molecule 2

1

4

High-throughput

0.445

High

332949

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

534870

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

697830

CALR
Calreticulin

1

2

High-throughput

0.445

High

698554

CALX
Calnexin

1

2

High-throughput

0.445

High

839447

PI4KA
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.445

High

963987

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.445

High

964003

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.445

High

964007

TMED2
Transmembrane emp24 domain-containing protein 2

1

3

High-throughput

0.445

High

964017

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.445

High

964021

LCLT1
Lysocardiolipin acyltransferase 1

1

1

High-throughput

0.445

High

964031

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.445

High

964040

SCFD1
Sec1 family domain-containing protein 1

1

1

High-throughput

0.445

High

964041

ATLA1
Atlastin-1

1

3

High-throughput

0.445

High

964057

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.445

High

964064

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

964070

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

964077

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.445

High

964086

DHRS7
Dehydrogenase/reductase SDR family member 7

1

3

High-throughput

0.445

High

964087

TMED5
Transmembrane emp24 domain-containing protein 5

1

3

High-throughput

0.445

High

588379

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

606540

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

695111

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

703924

DUS1
Dual specificity protein phosphatase 1

1

7

High-throughput

0.437

High

767868

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

963988

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

963997

DUS8
Dual specificity protein phosphatase 8

1

8

High-throughput

0.437

High

963998

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.437

High

964002

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

2

High-throughput

0.437

High

964012

E2F4
Transcription factor E2F4

1

2

High-throughput

0.437

High

964015

DUS28
Dual specificity phosphatase 28

1

8

High-throughput

0.437

High

964016

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.437

High

964020

SCYL2
SCY1-like protein 2

1

2

High-throughput

0.437

High

964022

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

964025

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

964028

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

964044

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

964067

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

50532

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

60322

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

211772

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

213585

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.426

High

215531

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

283229

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

359963

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

462322

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

876801

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

883080

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

963989

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

963996

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

964004

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

964005

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

964008

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

964010

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

964029

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

964030

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

964034

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

964036

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.426

High

964060

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

964061

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

964063

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

964076

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

964089

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

964059

TMED9
Transmembrane emp24 domain-containing protein 9

1

2

Small-scale

0.408

High

104330

F5H6I7
Atlastin GTPase 3

1

3

High-throughput

0.407

High

647461

UD11
UDP-glucuronosyltransferase 1A1

1

0

Small-scale

0.391

High

187052

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.279

Low

261615

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

769957

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.279

Low

946378

SIM11
Small integral membrane protein 11

1

0

High-throughput

0.279

Low

964006

RCN1
Reticulocalbin-1

1

0

High-throughput

0.279

Low

964027

TOM5
Mitochondrial import receptor subunit TOM5 homolog

1

0

High-throughput

0.279

Low

964033

SHCBP
SHC SH2 domain-binding protein 1

1

0

High-throughput

0.279

Low

964052

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.279

Low

964069

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.279

Low

254580

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

293481

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

925889

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.249

Low

963990

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

964045

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.249

Low

964080

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low

318971

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.232

Low

566954

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.232

Low

903668

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.232

Low

963994

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.232

Low

964001

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.232

Low

964050

SGF29
SAGA-associated factor 29

1

0

High-throughput

0.232

Low

964055

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

964058

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.232

Low

964072

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

964073

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

964075

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025