HitPredict

Interactor 1: HNRPK (P61978)
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
Gene: HNRNPK

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0048024 - regulation of mRNA splicing, via spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 463 Hs			1 164
+	Mm
		965988 HNRPK_MOUSE (1-463): 3.38e-139: 409: 100.00		SRSF3_MOUSE (1-164): 4.93e-28: 103: 100.00
+	Mm
		966040 HNRPK_MOUSE (1-463): 3.38e-139: 409: 100.00		SRSF7_MOUSE (7-115): 1.47e-26: 102: 60.55
+	Mm
		966028 HNRPK_MOUSE (1-463): 3.38e-139: 409: 100.00		SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65
+	Hs
		911531 HNRPK_HUMAN (1-463): 3.38e-139: 409: 100.00		NCBP2_HUMAN (9-117): 2.6e-26: 99.2: 24.56
+	Mm
		204682 HNRPK_MOUSE (1-463): 3.38e-139: 409: 100.00		SRSF5_MOUSE (10-112): 1.99e-24: 97: 44.34
+	Mm
		966112 HNRPK_MOUSE (1-463): 3.38e-139: 409: 100.00		SRS10_MOUSE (1-164): 2.26e-24: 96.6: 32.54
+	Hs
		550205 HNRPK_HUMAN (1-463): 3.38e-139: 409: 100.00		PABP1_HUMAN (1-91): 1.19e-20: 89.6: 25.77
+	Mm
		710981 HNRPK_MOUSE (1-463): 3.38e-139: 409: 100.00		PABP1_MOUSE (1-91): 1.35e-20: 89.2: 25.77
+	Hs
		965855 HNRPK_HUMAN (1-463): 3.38e-139: 409: 100.00		RBM4_HUMAN (11-88): 1.22e-19: 85.7: 28.21
+	Mm
		966045 HNRPK_MOUSE (1-463): 3.38e-139: 409: 100.00		RBM4_MOUSE (11-88): 2.62e-19: 84.6: 28.21
+	Hs
		1016691 IF2B2_HUMAN (6-454): 1.29e-76: 252: 16.16		SRSF3_HUMAN (1-164): 4.93e-28: 103: 100.00
+	Hs
		1102147 IF2B2_HUMAN (6-454): 1.29e-76: 252: 16.16		PABP4_HUMAN (5-91): 1.48e-21: 91.9: 26.09
+	Hs
		550547 IF2B2_HUMAN (6-454): 1.29e-76: 252: 16.16		PABP1_HUMAN (1-91): 1.19e-20: 89.6: 25.77
+	Hs
		1029055 IF2B2_HUMAN (6-454): 1.29e-76: 252: 16.16		TIAR_HUMAN (1-93): 4.21e-18: 81.5: 26.53
+	Hs
		1102118 IF2B1_HUMAN (1-461): 7.01e-66: 223: 14.71		PABP4_HUMAN (5-91): 1.48e-21: 91.9: 26.09
+	Hs
		550500 IF2B1_HUMAN (1-461): 7.01e-66: 223: 14.71		PABP1_HUMAN (1-91): 1.19e-20: 89.6: 25.77
+	Dm
		2561 NOVA_DROME (40-220): 6.64e-33: 134: 25.67		Q9VYD8_DROME (7-80): 2.08e-25: 97: 70.27
+	Dm
		2443 NOVA_DROME (40-220): 6.64e-33: 134: 25.67		RX21_DROME (10-81): 7.9e-22: 88.6: 54.17
+	Mm
		1209911 IF2B2_MOUSE (2-226): 1.94e-26: 114: 16.16		RBM4_MOUSE (11-88): 2.62e-19: 84.6: 28.21
+	Hs
		284153 PCBP2_HUMAN (127-222): 1.6e-12: 70.8: 29.17		SRS10_HUMAN (1-164): 2.26e-24: 96.6: 32.54