Protein: LYS12
Homoisocitrate dehydrogenase, mitochondrial (HIcDH) (EC 1.1.1.87)

Gene: LYS12
Organism: Saccharomyces cerevisiae S288C
Interactions: 166
UniProt ID: P40495

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004449 - isocitrate dehydrogenase (NAD+) activity
GO:0005739 - mitochondrion
GO:0006099 - tricarboxylic acid cycle
GO:0006102 - isocitrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

657076

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

12

High-throughput

0.691

High

774656

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

2

3

High-throughput

0.611

High

543875

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.584

High

680769

HS104
Heat shock protein 104

3

4

Small-scale

0.578

High

343126

THDH
Threonine dehydratase, mitochondrial

2

3

High-throughput

0.571

High

604426

CLH
Clathrin heavy chain

2

1

High-throughput

0.567

High

774640

COPB2
Coatomer subunit beta'

2

8

High-throughput

0.565

High

774657

ERG13
Hydroxymethylglutaryl-CoA synthase

2

0

High-throughput

0.563

High

774683

JID1
J domain-containing protein 1

2

0

High-throughput

0.563

High

768614

SSB2
Ribosome-associated molecular chaperone SSB2

3

6

High-throughput

0.558

High

366412

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.558

High

764070

RV167
Reduced viability upon starvation protein 167

2

3

High-throughput

0.549

High

687955

IMB3
Importin subunit beta-3

2

6

High-throughput

0.537

High

774642

EMW1
Essential for maintenance of the cell wall protein 1

2

2

High-throughput

0.537

High

774658

CTR9
RNA polymerase-associated protein CTR9

2

1

High-throughput

0.537

High

424556

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.536

High

703159

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.536

High

707873

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.536

High

774637

MAM33
Mitochondrial acidic protein MAM33

1

1

High-throughput

0.536

High

774659

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

High-throughput

0.536

High

774674

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.513

High

754469

SSZ1
Ribosome-associated complex subunit SSZ1

2

1

High-throughput

0.504

High

733382

CAF4
CCR4-associated factor 4

1

8

High-throughput

0.500

High

360907

TBB
Tubulin beta chain

1

1

High-throughput

0.489

High

412472

KIN28
Serine/threonine-protein kinase KIN28

1

5

High-throughput

0.489

High

454358

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.489

High

540105

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.489

High

605358

HSP74
Heat shock protein SSA4

1

6

High-throughput

0.489

High

644906

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.489

High

676120

XPO1
Exportin-1

1

1

High-throughput

0.489

High

687398

EF2
Elongation factor 2

1

1

High-throughput

0.489

High

691230

MKK2
MAP kinase kinase MKK2/SSP33

1

4

High-throughput

0.489

High

704132

CSE1
Importin alpha re-exporter

1

4

High-throughput

0.489

High

752917

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.489

High

767657

IMB4
Importin subunit beta-4

1

3

High-throughput

0.489

High

774643

RSSA2
Small ribosomal subunit protein uS2B

1

5

High-throughput

0.489

High

774654

COPA
Coatomer subunit alpha

1

8

High-throughput

0.489

High

774664

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.489

High

774666

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.489

High

774668

KU80
ATP-dependent DNA helicase II subunit 2

1

3

High-throughput

0.489

High

411017

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.479

High

478259

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.479

High

482295

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

705264

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.479

High

732915

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

764964

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

774665

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.479

High

774670

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.479

High

731054

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

752070

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.458

High

758939

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.458

High

424876

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.457

High

565635

PHO85
Cyclin-dependent protein kinase PHO85

1

6

High-throughput

0.457

High

594332

PP11
Serine/threonine-protein phosphatase PP1-1

1

3

High-throughput

0.457

High

746506

IMB2
Importin subunit beta-2

1

5

High-throughput

0.457

High

759117

DUN1
DNA damage response protein kinase DUN1

1

3

High-throughput

0.457

High

774651

RPN14
26S proteasome regulatory subunit RPN14

1

11

High-throughput

0.457

High

368130

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

440046

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

494154

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

520842

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.445

High

705921

XPOT
Exportin-T

1

2

High-throughput

0.445

High

774644

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

774680

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.445

High

141372

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

339682

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.437

High

358101

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

383187

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

405663

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

407099

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.437

High

407957

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

413548

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

425992

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

471097

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472231

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

480143

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

480710

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

485750

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.437

High

524339

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

606035

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.437

High

606668

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.437

High

628147

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

631921

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.437

High

638777

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

645487

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

662433

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

700455

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.437

High

706314

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

714897

PEX5
Peroxisomal targeting signal receptor

1

2

High-throughput

0.437

High

716261

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

716442

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

729950

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

742834

GBLP
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.437

High

752492

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

753407

ECM29
Proteasome component ECM29

1

3

High-throughput

0.437

High

774647

HLJ1
Protein HLJ1

1

1

High-throughput

0.437

High

774649

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

774660

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

774671

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

774673

SUB2
ATP-dependent RNA helicase SUB2

1

3

High-throughput

0.437

High

774676

MCA1
Metacaspase-1

1

1

High-throughput

0.437

High

774677

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

774681

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

774682

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.437

High

389647

DNLI1
DNA ligase 1

1

0

High-throughput

0.426

High

389930

VDAC1
Mitochondrial outer membrane protein porin 1

1

0

High-throughput

0.426

High

421649

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

650309

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

690082

APE2
Aminopeptidase 2, mitochondrial

1

0

High-throughput

0.426

High

699639

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.426

High

771368

PSA4
Proteasome subunit alpha type-4

1

0

High-throughput

0.426

High

399500

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

454616

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.407

High

491454

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.407

High

550055

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.407

High

556093

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

663878

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.407

High

705889

IXR1
Intrastrand cross-link recognition protein

1

3

High-throughput

0.407

High

757427

SPT8
Transcription factor SPT8

1

1

High-throughput

0.407

High

774228

MET18
DNA repair/transcription protein MET18/MMS19

1

2

High-throughput

0.407

High

774645

NMD5
Nonsense-mediated mRNA decay protein 5

1

4

High-throughput

0.407

High

774646

MET5
Sulfite reductase [NADPH] subunit beta

1

1

High-throughput

0.407

High

774653

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.407

High

774667

SXM1
Importin beta SMX1

1

5

High-throughput

0.407

High

774678

AP1G1
AP-1 complex subunit gamma-1

1

1

High-throughput

0.407

High

774685

SKS1
Serine/threonine-protein kinase SKS1

1

3

High-throughput

0.407

High

657245

URA7
CTP synthase 1

3

0

High-throughput

0.335

High

774684

AHA1
Hsp90 co-chaperone AHA1

2

0

High-throughput

0.318

High

774675

CDC45
Cell division control protein 45

2

0

High-throughput

0.313

High

627630

NAP1
Nucleosome assembly protein

2

0

High-throughput

0.307

High

755532

GGA2
ADP-ribosylation factor-binding protein GGA2

2

0

High-throughput

0.307

High

774638

LCB2
Serine palmitoyltransferase 2

2

0

High-throughput

0.307

High

747151

RXT2
Transcriptional regulatory protein RXT2

1

0

High-throughput

0.279

Low

752839

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

763426

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.279

Low

774639

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.279

Low

774641

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

756100

YHT8
Uncharacterized protein YHR138C

1

0

High-throughput

0.269

Low

774648

YPT11
GTP-binding protein YPT11

1

0

High-throughput

0.269

Low

774652

ART5
Arrestin-related trafficking adapter 5

1

0

High-throughput

0.269

Low

774661

OSH6
Oxysterol-binding protein homolog 6

1

0

High-throughput

0.269

Low

498532

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.249

Low

745702

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

749071

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

774672

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

774679

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

356523

H4
Histone H4

1

0

High-throughput

0.232

Low

452550

KEX1
Pheromone-processing carboxypeptidase KEX1

1

0

High-throughput

0.232

Low

589487

ZRC1
Vacuolar zinc transporter ZRC1

1

0

High-throughput

0.232

Low

629427

PUF4
Pumilio homology domain family member 4

1

0

High-throughput

0.232

Low

633286

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low

659166

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.232

Low

690509

HXT4
Low-affinity glucose transporter HXT4

1

0

High-throughput

0.232

Low

693407

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.232

Low

697590

KA122
Importin beta-like protein KAP122

1

0

High-throughput

0.232

Low

704174

DOM34
Protein DOM34

1

0

High-throughput

0.232

Low

752041

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.232

Low

753840

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.232

Low

762132

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

768148

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

0

High-throughput

0.232

Low

774650

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.232

Low

774655

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.232

Low

774662

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

High-throughput

0.232

Low

774663

VPS16
Vacuolar protein sorting-associated protein 16

1

0

High-throughput

0.232

Low

774669

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.232

Low

774686

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024