HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: SRSF9 (Q13242)
Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)
Gene: SRSF9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24999758
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 656 Hs			1 221
+	Hs
		992865 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95
+	Mm
		1207139 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		SRSF9_MOUSE (2-221): 5.95e-54: 173: 98.64
+	Hs
		1029024 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SRSF6_HUMAN (15-176): 1.67e-51: 171: 36.67
+	Hs
		967128 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95
+	Hs
		967149 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SRSF6_HUMAN (15-176): 1.67e-51: 171: 36.67
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (12-193): 1.8e-42: 153: 20.00
+	Hs
		967197 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SF3B4_HUMAN (1-211): 2.82e-49: 167: 15.32
+	Hs
		967129 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SRSF4_HUMAN (15-169): 2.97e-47: 164: 39.52
+	Hs
		318621 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		SF3B4_HUMAN (1-211): 2.82e-49: 167: 15.32
+	Hs
		726769 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95
+	Hs
		726791 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SRSF9_HUMAN (1-221): 1.6e-55: 178: 100.00
+	Hs
		726792 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SRSF5_HUMAN (12-176): 4.58e-54: 176: 35.20
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (5-104): 2.37e-21: 93.4: 19.80
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (12-193): 1.8e-42: 153: 20.00
+	Sc
		757864 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		NOP3_YEAST (7-179): 6.54e-38: 137: 27.68
+	Mm
		1207135 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		RBM4_MOUSE (110-185): 1.67e-16: 78.8: 18.42
+	Hs
		318712 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		RBM4B_HUMAN (5-102): 8.16e-18: 82.6: 20.41
+	Hs
		318716 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		RBM4_HUMAN (110-185): 1.92e-16: 78.8: 18.42
+	Hs
		318604 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		TIAR_HUMAN (103-192): 2.42e-13: 69.9: 11.58
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (113-192): 2.4e-13: 70.3: 20.69