HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	24999758, 29884807
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 656 Hs			1 238
+	Hs
		1084353 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		432837 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Mm
		952207 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		SRSF3_MOUSE (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Hs
		992865 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		951928 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		967128 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Mm
		1207135 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		RBM4_MOUSE (12-89): 2.3e-14: 73.3: 33.33
+	Hs
		726852 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		318712 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		RBM4B_HUMAN (12-89): 4.32e-17: 81: 32.05
+	Hs
		318604 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		TIAR_HUMAN (5-97): 6.64e-16: 77.8: 25.51
+	Hs
		726675 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42
+	Hs
		432577 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		726746 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		318716 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		RBM4_HUMAN (12-89): 4.44e-14: 72.2: 33.33
+	Hs
		726795 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (7-95): 4.44e-17: 81.7: 22.34
+	Hs
		726769 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11