HitPredict

Interactor 1: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	11044439, 10523642
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005078 - MAP-kinase scaffold activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 393 Hs			1 1336
+	Mm
		682480 MP2K1_MOUSE (1-393): 9.74e-125: 367: 98.98		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		805489 MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Hs
		153188 MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Hs
		801006 MP2K4_HUMAN (66-388): 2.41e-60: 202: 36.20		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Mm
		814033 MP2K4_MOUSE (66-388): 4.79e-61: 203: 36.20		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		229635 MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		229642 MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		229641 MP2K4_HUMAN (66-388): 2.41e-60: 202: 36.20		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		625530 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		MY18A_HUMAN (189-793): 1.74e-25: 117: 9.00
+	Hs
		625177 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		625176 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		681696 AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		551624 MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		551610 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		551616 AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		148286 CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45		CTRO_HUMAN (1-425): 1.46e-17: 91.4: 9.17
+	Hs
		414713 CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		1023100 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Hs
		551881 STK24_HUMAN (65-364): 1.58e-102: 312: 32.12		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		131598 STK25_HUMAN (50-367): 4.36e-103: 312: 31.88		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56