Protein: US6NL
USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)

Gene: US6NL, USP6NL
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q92738

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007030 - Golgi organization
GO:0019068 - virion assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375797

RASK
GTPase KRas

3

19

High-throughput

0.827

High

374109

RASN
GTPase NRas

2

20

High-throughput

0.754

High

978209

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

126731

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

341118

DIRA3
GTP-binding protein Di-Ras3

1

12

High-throughput

0.618

High

374824

RASH
GTPase HRas

1

15

High-throughput

0.618

High

581212

RAC2
Ras-related C3 botulinum toxin substrate 2

1

16

High-throughput

0.618

High

601395

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

910154

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

953601

RAC3
Ras-related C3 botulinum toxin substrate 3

1

18

High-throughput

0.618

High

955442

CDC42
Cell division control protein 42 homolog

1

19

High-throughput

0.618

High

962342

RHOA
Transforming protein RhoA

1

18

High-throughput

0.618

High

962799

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

988584

RAC1
Ras-related C3 botulinum toxin substrate 1

1

18

High-throughput

0.618

High

1015649

RHOG
Rho-related GTP-binding protein RhoG

1

16

High-throughput

0.618

High

1145048

RAB35
Ras-related protein Rab-35

1

13

High-throughput

0.618

High

1151807

RHOH
Rho-related GTP-binding protein RhoH

1

19

High-throughput

0.618

High

1270930

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1367845

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1367847

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

132195

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

2

High-throughput

0.611

High

975161

ARF6
ADP-ribosylation factor 6

2

6

High-throughput

0.611

High

422764

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.602

High

1311637

KIBRA
Protein KIBRA

2

2

High-throughput

0.601

High

710406

EPHA2
Ephrin type-A receptor 2

2

13

High-throughput

0.584

High

396637

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

629147

CCNA2
Cyclin-A2

1

1

High-throughput

0.536

High

642267

COMT
Catechol O-methyltransferase

1

1

High-throughput

0.536

High

902394

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

1

High-throughput

0.536

High

1162685

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

2

High-throughput

0.536

High

1286452

DSG4
Desmoglein-4

1

4

High-throughput

0.536

High

948570

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1353640

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.513

High

987811

GRB2
Growth factor receptor-bound protein 2

1

4

Small-scale

0.501

High

720292

UFO
Tyrosine-protein kinase receptor UFO

1

14

High-throughput

0.500

High

326758

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.489

High

595540

H15
Histone H1.5

1

2

High-throughput

0.489

High

48725

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

181810

EPHB6
Ephrin type-B receptor 6

1

12

High-throughput

0.479

High

189755

STX7
Syntaxin-7

1

5

High-throughput

0.479

High

363665

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

412367

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

440163

LCK
Tyrosine-protein kinase Lck

1

2

High-throughput

0.479

High

463689

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.479

High

540603

LAMP1
Lysosome-associated membrane glycoprotein 1

1

8

High-throughput

0.479

High

541619

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

556258

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

604138

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

641226

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.479

High

643003

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

648614

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

691305

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

710873

EPHB2
Ephrin type-B receptor 2

1

11

High-throughput

0.479

High

715704

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

730116

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730808

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

845744

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.479

High

931878

EPHA5
Ephrin type-A receptor 5

1

14

High-throughput

0.479

High

932110

EPHA4
Ephrin type-A receptor 4

1

12

High-throughput

0.479

High

936405

AFAD
Afadin

1

11

High-throughput

0.479

High

966699

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

971847

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.479

High

990570

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1004152

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.479

High

1034184

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.479

High

1034309

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

1041210

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1045589

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1049638

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1055076

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

14

High-throughput

0.479

High

1137906

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1140641

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1147399

EPHA7
Ephrin type-A receptor 7

1

12

High-throughput

0.479

High

1157018

NTRK3
NT-3 growth factor receptor

1

19

High-throughput

0.479

High

1159523

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

1159786

OCLN
Occludin

1

1

High-throughput

0.479

High

1233396

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1235309

STYK1
Tyrosine-protein kinase STYK1

1

13

High-throughput

0.479

High

1322927

CXD3
Gap junction delta-3 protein

1

4

High-throughput

0.479

High

1353239

PARD3
Partitioning defective 3 homolog

1

4

High-throughput

0.479

High

1367843

SNX27
Sorting nexin-27

1

7

High-throughput

0.479

High

1367846

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1367851

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1367852

ALK
ALK tyrosine kinase receptor

1

14

High-throughput

0.479

High

224768

ACTN4
Alpha-actinin-4

1

0

Small-scale

0.458

High

299320

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

764933

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

1229019

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1367844

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1367849

ANLN
Anillin

1

0

High-throughput

0.458

High

1367850

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

327392

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

1004915

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1254891

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1276262

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

1289258

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

High-throughput

0.437

High

1367842

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1367848

E41LA
Band 4.1-like protein 4A

1

2

High-throughput

0.437

High

516705

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

2

High-throughput

0.407

High

1090357

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

Small-scale

0.324

High

1364802

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

248020

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

1293101

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025