HitPredict

Interactor 1: TIE2 (Q02763)
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Gene: TEK

Interactor 2: ANGP1 (Q15389)
Angiopoietin-1 (ANG-1)
Gene: ANGPT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

The method score is based on:

Property	Details
Experiments	12427764, 8980223, 9723709, 9204896, 29106382, 20708158
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0001934 - positive regulation of protein phosphorylation GO:0002040 - sprouting angiogenesis GO:0005576 - extracellular region GO:0005886 - plasma membrane and 9 others more... GO:0005902 - microvillus GO:0010595 - positive regulation of endothelial cell migration GO:0043066 - negative regulation of apoptotic process GO:0045121 - membrane raft GO:0048014 - Tie signaling pathway GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0072012 - glomerulus vasculature development GO:2000352 - negative regulation of endothelial cell apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	1124
Hs

1	498

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024