HitPredict

Interactor 1: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.759

The method score is based on:

Property Details
Experiments 12419806, 30670829, 11931769, 11564889, 20001970, 17000776, 16483679, 15192014, 17827154, 27012186, 35346238, 21983014, 16291753
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0005634 - nucleus
and 15 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 551
Hs

1 482
+ Hs
+ Rn
+ Mm
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024