HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	33961781, 19503073
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	EGF~FXa_inhibition, EGF_CA~FXa_inhibition
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region GO:0009986 - cell surface
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2471 Hs			1 273
+	Mm
		192834 NOTC2_MOUSE (1-2471): 0: 1344: 92.32		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		296652 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		SLIT2_HUMAN (3-138): 1.42e-12: 69.5: 11.77
+	Hs
		980413 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		NPNT_HUMAN (80-173): 1.51e-11: 65.9: 32.35
+	Hs
		944119 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		804213 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		804361 NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		804198 NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88		JAG1_HUMAN (66-168): 1.68e-10: 63.2: 28.57
+	Hs
		804163 NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Dm
		65546 A8JNM5_DROME (1567-2286): 4.23e-109: 394: 13.70		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Mm
		681672 NOTC4_MOUSE (1-841): 1.65e-76: 286: 28.03		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		1303971 NOTC4_HUMAN (1-768): 9.63e-67: 254: 27.20		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Dm
		246781 Q0KIE7_DROME (1883-2289): 5.8e-70: 263: 13.62		TENM_DROME (4-250): 1.41e-23: 102: 12.37
+	Mm
		966335 NOTC1_MOUSE (1-656): 5.93e-55: 215: 28.63		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		724358 FBN1_HUMAN (201-1638): 9.66e-69: 261: 18.41		FBLN5_HUMAN (13-187): 8.52e-09: 57.5: 17.46
+	Hs
		804379 JAG2_HUMAN (2-501): 6.2e-66: 249: 33.21		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Dr
		60071 A4JYS0_DANRE (25-180): 3.47e-23: 109: 42.41		A4JYS0_DANRE (41-186): 6.71e-16: 79.1: 23.18
+	Dm
		90684 NOTCH_DROME (2-344): 3.6e-21: 104: 21.89		E1JHA6_DROME (2-138): 3.95e-12: 68.3: 13.61
+	Dm
		422709 NOTCH_DROME (2-344): 3.6e-21: 104: 21.89		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Dm
		422713 NOTCH_DROME (2-344): 3.6e-21: 104: 21.89		DL_DROME (53-168): 1.69e-09: 60.1: 25.58