HitPredict

Interactor 1: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Interactor 2: HES1 (Q14469)
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)
Gene: HES1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	9874198
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 743 Hs			1 280
+	Hs
		980604 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		HES1_HUMAN (1-280): 2.76e-97: 288: 100.00
+	Hs
		980671 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		HEY1_HUMAN (7-278): 1.4e-64: 206: 29.62
+	Hs
		980651 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		HES4_HUMAN (1-205): 1.7e-52: 172: 54.59
+	Hs
		980948 TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93		HES6_HUMAN (11-228): 1.12e-47: 160: 29.68
+	Hs
		980638 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		HES6_HUMAN (11-228): 1.12e-47: 160: 29.68
+	Mm
		1143960 TLE1_MOUSE (1-743): 8.54e-171: 511: 63.12		HES6_MOUSE (11-228): 2.62e-46: 156: 25.11
+	Hs
		980840 TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91		HES6_HUMAN (11-228): 1.12e-47: 160: 29.68
+	Dm
		558377 GROU_DROME (1-743): 8.48e-144: 440: 54.69		DPN_DROME (30-243): 1.16e-54: 184: 42.13
+	Dm
		558369 GROU_DROME (1-743): 8.48e-144: 440: 54.69		ESM3_DROME (26-278): 6.31e-54: 176: 22.73
+	Dm
		558371 GROU_DROME (1-743): 8.48e-144: 440: 54.69		ESMC_DROME (22-163): 1.05e-52: 172: 34.03
+	Dm
		558370 GROU_DROME (1-743): 8.48e-144: 440: 54.69		ESMB_DROME (25-198): 1.08e-51: 169: 27.23
+	Dm
		525718 GROU_DROME (1-743): 8.48e-144: 440: 54.69		ESM7_DROME (24-163): 1.21e-48: 161: 32.86
+	Dm
		525743 GROU_DROME (1-743): 8.48e-144: 440: 54.69		ESM8_DROME (28-203): 2.3e-48: 160: 20.67
+	Dm
		558372 GROU_DROME (1-743): 8.48e-144: 440: 54.69		ESMD_DROME (28-190): 8.42e-48: 159: 29.76
+	Dm
		558399 GROU_DROME (1-743): 8.48e-144: 440: 54.69		Q9VJ16_DROME (21-264): 1.49e-44: 159: 27.31
+	Dm
		534341 GROU_DROME (1-743): 8.48e-144: 440: 54.69		HAIR_DROME (13-236): 2.15e-43: 152: 41.85
+	Dm
		558409 GROU_DROME (1-743): 8.48e-144: 440: 54.69		Q9VWX7_DROME (14-158): 6.05e-45: 150: 27.33
+	Dm
		525705 GROU_DROME (1-743): 8.48e-144: 440: 54.69		ESM5_DROME (17-203): 2.87e-41: 142: 21.39
+	Hs
		62468 TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89		HELT_HUMAN (28-277): 6.1e-44: 151: 25.58
+	Hs
		421 TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89		A0A087WSW0_HUMAN (2-277): 1.02e-42: 150: 20.50