HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: TRAF7 (Q6Q0C0)
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
Gene: TRAF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~WD40, UQ_con~zf-RING_UBOX
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 670
+	Hs
		1246181 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		TRAF7_HUMAN (1-670): 1.87e-178: 525: 100.00
+	Hs
		906680 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		TRAF7_HUMAN (1-670): 1.87e-178: 525: 100.00
+	Hs
		906830 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		FBW1A_HUMAN (146-669): 8.56e-102: 325: 16.91
+	Hs
		982372 UB2D2_HUMAN (1-147): 1.58e-82: 240: 100.00		FBW1A_HUMAN (146-669): 8.56e-102: 325: 16.91
+	Hs
		957246 UB2D3_HUMAN (1-147): 2.22e-81: 237: 97.28		FBW1A_HUMAN (146-669): 8.56e-102: 325: 16.91
+	Hs
		906772 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		TBL1R_HUMAN (189-548): 2.17e-50: 185: 14.92
+	Hs
		1381199 UB2E3_HUMAN (4-146): 5.71e-74: 221: 66.43		TBL1R_HUMAN (189-548): 2.17e-50: 185: 14.92
+	Dm
		232057 UBCD1_DROME (1-147): 4.19e-82: 239: 94.56		O44382_DROME (140-471): 3.63e-32: 132: 16.09
+	Hs
		957805 UBE2N_HUMAN (4-147): 1.73e-68: 205: 47.22		FBXW7_HUMAN (178-499): 1.81e-31: 132: 14.97
+	Hs
		957234 UB2D3_HUMAN (1-147): 2.22e-81: 237: 97.28		FBW1B_HUMAN (123-384): 9.62e-09: 60.5: 10.33