HitPredict

Interactor 1: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 457
+	Hs
		684651 FAK1_HUMAN (1-1052): 0: 1127: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		561387 FER_HUMAN (86-682): 1.71e-137: 436: 24.84		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		426957 FES_HUMAN (85-681): 2.15e-126: 406: 22.89		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		201328 M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		426954 FES_HUMAN (85-681): 2.15e-126: 406: 22.89		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		374182 RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		872531 EPHB4_HUMAN (394-760): 1.25e-115: 382: 33.60		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		201309 M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		374083 RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118687 FER_HUMAN (86-682): 1.71e-137: 436: 24.84		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		426955 FES_HUMAN (85-681): 2.15e-126: 406: 22.89		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		374114 RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		375059 RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		118664 RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118695 EPHA8_HUMAN (387-760): 8.96e-116: 383: 33.69		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118671 FYN_HUMAN (265-689): 7.19e-119: 377: 26.68		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118683 SRC_HUMAN (415-689): 1.19e-113: 363: 38.77		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118675 YES_HUMAN (415-689): 7.31e-112: 359: 37.68		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118670 LCK_HUMAN (412-691): 7.42e-111: 355: 37.37		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		373773 RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62