HitPredict

Interactor 1: NMDZ1 (Q05586)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
Gene: GRIN1

Interactor 2: LNX1 (Q8TBB1)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	22889411
Identification Methods	two hybrid, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 938 Hs			1 728
+	Mm
		723600 NMDZ1_MOUSE (1-938): 0: 936: 99.04		DLG1_MOUSE (331-728): 7.2e-29: 125: 17.16
+	Hs
		984257 NMDZ1_HUMAN (1-938): 0: 935: 100.00		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Mm
		723586 NMDZ1_MOUSE (1-938): 0: 936: 99.04		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Rn
		677765 NMDZ1_RAT (1-938): 0: 936: 99.25		DLG4_RAT (267-582): 6.83e-21: 99.8: 16.09
+	Hs
		942329 NMDZ1_HUMAN (1-938): 0: 935: 100.00		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Mm
		57144 A2AI21_MOUSE (1-938): 0: 925: 96.77		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Rn
		291493 NMDZ1_RAT (1-938): 0: 936: 99.25		MAGI2_RAT (121-422): 3.25e-17: 88.6: 11.22
+	Rn
		723628 NMDZ1_RAT (1-938): 0: 936: 99.25		DLG3_RAT (523-713): 8.18e-16: 83.6: 17.62
+	Mm
		723568 NMDZ1_MOUSE (1-938): 0: 936: 99.04		DLG3_MOUSE (523-713): 1.28e-15: 83.2: 20.21
+	Rn
		723633 NMDZ1_RAT (1-938): 0: 936: 99.25		NHRF3_RAT (251-402): 3.11e-11: 68.6: 15.79
+	Mm
		723606 NMDZ1_MOUSE (1-938): 0: 936: 99.04		DLG2_MOUSE (352-500): 5.83e-11: 68.2: 17.95
+	Hs
		1021483 GRIK2_HUMAN (3-901): 0: 745: 22.55		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Hs
		942335 GRIK2_HUMAN (3-901): 0: 745: 22.55		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Rn
		677766 GRIK2_RAT (3-901): 0: 743: 22.55		DLG4_RAT (267-582): 6.83e-21: 99.8: 16.09
+	Mm
		761217 GRIK2_MOUSE (3-901): 0: 742: 22.55		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Hs
		786696 GRIA1_HUMAN (6-904): 0: 703: 21.38		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Hs
		761199 GRIK1_HUMAN (5-869): 0: 726: 23.33		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Hs
		1022366 GRIK2_HUMAN (3-901): 0: 745: 22.55		DLG3_HUMAN (619-713): 1.3e-14: 79.7: 28.87
+	Rn
		585138 GRIA1_RAT (6-904): 0: 696: 21.15		DLG4_RAT (267-582): 6.83e-21: 99.8: 16.09
+	Dm
		677690 NMDA1_DROME (4-928): 0: 703: 44.35		DLG1_DROME (602-726): 2.88e-12: 72.6: 27.56