Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11
Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 0.60 | 0.765 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 14701753, 20473329, 11453982, 9632795, 23612964, 24728074, 11940581, 9658397, 9804835, 14982882, 11027663, 24935154, 12855672, 15574420, 11323411, 20308328, 14665621 |
| Identification Methods | affinity chromatography technology, unspecified method, pull down, two hybrid, far western blotting, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation, phosphatase assay, surface plasmon resonance and 1 others
more... |
| Interaction Type | physical association, direct interaction, association, dephosphorylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007173 - epidermal growth factor receptor signaling pathway |
| Homologous interactions | 15 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
