HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.50	0.565

Property	Details
Experiments	10358138, 24642916
Identification Methods	affinity chromatography technology, pull down, surface plasmon resonance
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 370
+	Hs
		665951 PTN6_HUMAN (6-593): 0: 531: 55.27		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		986050 PTN11_HUMAN (1-593): 0: 581: 100.00		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Hs
		986009 PTN11_HUMAN (1-593): 0: 581: 100.00		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		532367 PTN11_HUMAN (1-593): 0: 581: 100.00		CEAM1_HUMAN (8-323): 2.01e-48: 172: 17.47
+	Hs
		986036 PTN11_HUMAN (1-593): 0: 581: 100.00		LY9_HUMAN (4-238): 1.56e-46: 169: 21.25
+	Hs
		985949 PTN11_HUMAN (1-593): 0: 581: 100.00		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		665937 PTN6_HUMAN (6-593): 0: 531: 55.27		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		532361 PTN6_HUMAN (6-593): 0: 531: 55.27		CEAM1_HUMAN (8-323): 2.01e-48: 172: 17.47
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 581: 100.00		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Mm
		682308 PTN11_MOUSE (1-593): 0: 580: 99.49		CEAM1_MOUSE (71-211): 1.25e-11: 67.7: 18.44
+	Hs
		665883 PTN6_HUMAN (6-593): 0: 531: 55.27		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Hs
		1031992 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		CEA21_HUMAN (6-280): 1.9e-50: 172: 16.78
+	Hs
		489970 PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85		CEA21_HUMAN (6-280): 1.9e-50: 172: 16.78
+	Hs
		68228 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		HECA2_HUMAN (18-355): 2.35e-32: 128: 13.26
+	Hs
		68222 PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85		HECA2_HUMAN (18-355): 2.35e-32: 128: 13.26
+	Hs
		573657 PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Hs
		685236 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		CEAM8_HUMAN (55-250): 2.04e-18: 87.3: 12.25
+	Hs
		441196 PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		416911 PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Mm
		530202 PTPRA_MOUSE (33-522): 1.27e-110: 351: 23.52		NCAM1_MOUSE (5-352): 1.69e-20: 95.4: 11.59