Interactor 1: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK
Interactor 2: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.93 | 1.00 | 0.968 |
The method score is based on:
Property | Details |
---|---|
Experiments | 29290977, 11527964, 11373296, 10427990, 8630736, 17932028, 11577348, 11231015 |
Identification Methods | enzymatic study, x-ray crystallography, affinity chromatography technology, protein kinase assay |
Interaction Type | direct interaction, association, physical association, phosphorylation reaction |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | BTK~BTK, BTK~PH, PH~PH, PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1 |
Common GO terms | GO:0001780 - neutrophil homeostasis GO:0001805 - positive regulation of type III hypersensitivity GO:0001812 - positive regulation of type I hypersensitivity GO:0002250 - adaptive immune response GO:0002344 - B cell affinity maturation and 49 others more... |
Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024