Interactor 1: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Interactor 2: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.968

The method score is based on:

Property Details
Experiments 29290977, 11527964, 11373296, 10427990, 8630736, 17932028, 11577348, 11231015
Identification Methods enzymatic study, x-ray crystallography, affinity chromatography technology, protein kinase assay
Interaction Type direct interaction, association, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains BTK~BTK, BTK~PH, PH~PH, PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms GO:0001780 - neutrophil homeostasis
GO:0001805 - positive regulation of type III hypersensitivity
GO:0001812 - positive regulation of type I hypersensitivity
GO:0002250 - adaptive immune response
GO:0002344 - B cell affinity maturation
and 49 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024