HitPredict

Interactor 1: PSME1 (Q06323)
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)
Gene: PSME1

Interactor 2: PSME1 (Q06323)
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)
Gene: PSME1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

The method score is based on:

Property	Details
Experiments	25416956, 16169070, 9403698, 35235311, 9385652, 9325261
Identification Methods	two hybrid, x-ray crystallography, cross-linking study, pull down, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, association, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	PA28_alpha~PA28_alpha, PA28_alpha~PA28_beta, PA28_beta~PA28_beta
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008537 - proteasome activator complex and 5 others more... GO:0019884 - antigen processing and presentation of exogenous antigen GO:0061133 - endopeptidase activator activity GO:0061136 - regulation of proteasomal protein catabolic process GO:0070062 - extracellular exosome GO:2000045 - regulation of G1/S transition of mitotic cell cycle
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	249
Hs

1	249

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024