HitPredict

Interactor 1: SUH (Q06330)
Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)
Gene: RBPJ

Interactor 2: NOTC3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Gene: NOTCH3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.929

The method score is based on:

Property Details
Experiments 25356737, 26186194, 25609649, 28514442, 33961781
Identification Methods pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~BTD, Ank_2~LAG1-DNAbind, Ank_2~TIG_SUH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005654 - nucleoplasm
GO:0007219 - Notch signaling pathway
GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 500
Hs

1 2321
+ Mm
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ Mm
+ Mm
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024