Protein: CUL3
Cullin-3 (CUL-3)

Gene: CUL3
Organism: Mus musculus
Interactions: 43
UniProt ID: Q9JLV5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0000278 - mitotic cell cycle
GO:0000902 - cell morphogenesis
GO:0000922 - spindle pole

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1440934

KEAP1
Kelch-like ECH-associated protein 1

2

20

Small-scale

0.754

High

1193963

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

13

High-throughput

0.691

High

104647

SYGP1
Ras/Rap GTPase-activating protein SynGAP

3

6

High-throughput

0.667

High

1190768

Q3UQ17
Zinc finger and BTB domain containing 16

1

20

Small-scale

0.618

High

1253362

IBTK
Inhibitor of Bruton tyrosine kinase

1

20

Small-scale

0.618

High

1257450

SPOP
Speckle-type POZ protein

1

20

High-throughput

0.618

High

1296400

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

20

High-throughput

0.618

High

1296679

FBXW8
F-box/WD repeat-containing protein 8

1

20

Small-scale

0.618

High

1317151

KLHL2
Kelch-like protein 2

1

20

Small-scale

0.618

High

1424094

KLH10
Kelch-like protein 10

1

20

Small-scale

0.618

High

1440932

CUL3
Cullin-3

1

17

Small-scale

0.618

High

509303

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

20

High-throughput

0.579

High

1274221

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

2

High-throughput

0.536

High

1424290

TSC1
Hamartin

1

16

High-throughput

0.536

High

148737

HDAC1
Histone deacetylase 1

1

12

Small-scale

0.479

High

204822

XBP1
X-box-binding protein 1

1

2

Small-scale

0.479

High

266620

DHX9
ATP-dependent RNA helicase A

1

20

Small-scale

0.479

High

480990

NUCL
Nucleolin

1

19

Small-scale

0.479

High

568905

DNMT1
DNA

1

11

Small-scale

0.479

High

575083

LMNB1
Lamin-B1

1

20

Small-scale

0.479

High

771507

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

High-throughput

0.479

High

772583

IRS1
Insulin receptor substrate 1

1

15

Small-scale

0.479

High

847047

H13
Histone H1.3

1

9

Small-scale

0.479

High

902810

RORG
Nuclear receptor ROR-gamma

1

11

Small-scale

0.479

High

943022

FUS
RNA-binding protein FUS

1

20

Small-scale

0.479

High

945984

EF2
Elongation factor 2

1

8

Small-scale

0.479

High

966110

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

20

Small-scale

0.479

High

1030131

TOP2A
DNA topoisomerase 2-alpha

1

4

Small-scale

0.479

High

1189348

HP1B3
Heterochromatin protein 1-binding protein 3

1

4

Small-scale

0.479

High

1221498

NF2L2
Nuclear factor erythroid 2-related factor 2

1

10

Small-scale

0.479

High

1222449

EZH2
Histone-lysine N-methyltransferase EZH2

1

13

Small-scale

0.479

High

1225679

SQSTM
Sequestosome-1

1

6

Small-scale

0.479

High

1274299

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

20

Small-scale

0.479

High

1297366

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

16

Small-scale

0.479

High

1354040

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

20

Small-scale

0.479

High

1362774

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

1408699

FOXP3
Forkhead box protein P3

1

4

High-throughput

0.479

High

1424381

DGCR8
Microprocessor complex subunit DGCR8

1

1

Small-scale

0.479

High

1440933

BAZ1B
Tyrosine-protein kinase BAZ1B

1

20

Small-scale

0.479

High

1298151

Q8C839
Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein

1

2

Small-scale

0.437

High

1317340

DDX18
ATP-dependent RNA helicase DDX18

1

19

Small-scale

0.437

High

1408953

NU155
Nuclear pore complex protein Nup155

1

3

Small-scale

0.437

High


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Last updated: 11Aug2025