HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	20936779, 21145461
Identification Methods	two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 334
+	At
		840478 14333_ARATH (3-239): 1.49e-141: 398: 64.73		CSN5B_ARATH (1-334): 8.5e-119: 348: 66.57
+	Hs
		966704 1433G_HUMAN (1-240): 2.38e-108: 314: 74.59		CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00
+	Hs
		730810 1433S_HUMAN (1-237): 8.31e-104: 302: 71.97		CSN5_HUMAN (1-334): 6.67e-131: 378: 100.00
+	Hs
		138060 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PSDE_HUMAN (50-331): 1.68e-79: 246: 31.51
+	Hs
		131388 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		EIF3F_HUMAN (44-328): 3.26e-64: 208: 14.48
+	Hs
		906506 1433F_HUMAN (2-240): 1.27e-107: 312: 74.49		PSMD7_HUMAN (52-325): 1.07e-66: 214: 14.79
+	Hs
		187898 1433S_HUMAN (1-237): 8.31e-104: 302: 71.97		EIF3H_HUMAN (52-320): 2.18e-66: 214: 18.57
+	Hs
		858760 1433G_HUMAN (1-240): 2.38e-108: 314: 74.59		BRCC3_HUMAN (56-203): 4.63e-43: 152: 21.23
+	Hs
		858766 1433F_HUMAN (2-240): 1.27e-107: 312: 74.49		BRCC3_HUMAN (56-203): 4.63e-43: 152: 21.23