HitPredict

Interactor 1: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Interactor 2: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	24981860, 33961781, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000380 - alternative mRNA splicing, via spliceosome GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0006376 - mRNA splice site recognition and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 344
+	Hs
		992750 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Hs
		992751 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Mm
		1208011 SRSF9_MOUSE (2-239): 1.21e-65: 204: 58.82		RBM4_MOUSE (1-343): 1.34e-43: 155: 18.18
+	Hs
		993700 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47
+	Hs
		992737 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Hs
		993701 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47
+	Hs
		1028637 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00
+	Hs
		474020 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		PAB4L_HUMAN (1-196): 1.97e-35: 134: 15.94
+	Mm
		857340 SRSF1_MOUSE (1-235): 1.04e-49: 165: 100.00		TIA1_MOUSE (2-335): 1.54e-33: 129: 15.46
+	Hs
		516493 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		1028845 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61
+	At
		186868 SR34_ARATH (14-243): 1.02e-62: 200: 46.42		RSZ33_ARATH (3-89): 5.6e-11: 64.3: 51.14
+	Hs
		1029129 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61
+	Hs
		951941 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84
+	Hs
		951942 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84
+	Hs
		993850 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		RBM28_HUMAN (4-248): 1.53e-12: 70.6: 14.61
+	Hs
		951933 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84