Protein: RRP1
Ribosomal RNA-processing protein 1

Gene: RRP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 138
UniProt ID: P35178

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
GO:0030687 - preribosome, large subunit precursor
GO:0030688 - preribosome, small subunit precursor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534096

MAK16
Protein MAK16

2

3

Small-scale

0.754

High

763051

RRP1
Ribosomal RNA-processing protein 1

2

2

Small-scale

0.754

High

763086

NOP2
25S rRNA

6

5

Small-scale

0.732

High

763097

PESC
Pescadillo homolog

6

2

Small-scale

0.730

High

763055

RPF2
Ribosome biogenesis protein RPF2

6

1

Small-scale

0.729

High

763075

NOC2
Nucleolar complex protein 2

6

2

Small-scale

0.723

High

763106

NOG1
Nucleolar GTP-binding protein 1

5

4

Small-scale

0.702

High

763067

CIC1
Proteasome-interacting protein CIC1

4

2

Small-scale

0.686

High

763095

NSA1
Ribosome biogenesis protein NSA1

4

2

Small-scale

0.676

High

763109

HAS1
ATP-dependent RNA helicase HAS1

4

10

Small-scale

0.676

High

763130

BRX1
Ribosome biogenesis protein BRX1

3

12

Small-scale

0.656

High

763136

YTM1
Ribosome biogenesis protein YTM1

3

6

Small-scale

0.656

High

763069

RPF1
Ribosome production factor 1

3

3

Small-scale

0.643

High

569962

RL3
Large ribosomal subunit protein uL3

3

2

Small-scale

0.640

High

763068

SSF1
Ribosome biogenesis protein SSF1

3

3

Small-scale

0.640

High

763085

RLP7
Ribosome biogenesis protein RLP7

3

3

Small-scale

0.640

High

763100

NOP15
Ribosome biogenesis protein 15

3

6

Small-scale

0.640

High

763118

RRP5
rRNA biogenesis protein RRP5

3

6

Small-scale

0.640

High

763142

MAK21
Ribosome biogenesis protein MAK21

3

6

Small-scale

0.640

High

763144

DBP10
ATP-dependent RNA helicase DBP10

3

6

Small-scale

0.640

High

763145

IF6
Eukaryotic translation initiation factor 6

3

2

Small-scale

0.640

High

434984

RS3
Small ribosomal subunit protein uS3

2

1

Small-scale

0.584

High

633148

MAK11
Protein MAK11

2

6

Small-scale

0.584

High

682232

SPB4
ATP-dependent rRNA helicase SPB4

2

8

High-throughput

0.584

High

746608

DRS1
ATP-dependent RNA helicase DRS1

2

9

Small-scale

0.584

High

763052

EBP2
rRNA-processing protein EBP2

2

2

Small-scale

0.584

High

763056

NOP4
Nucleolar protein 4

2

4

Small-scale

0.584

High

763078

NSA2
Ribosome biogenesis protein NSA2

2

1

Small-scale

0.584

High

763117

ERB1
Ribosome biogenesis protein ERB1

2

6

Small-scale

0.584

High

763128

RLP24
Ribosome biogenesis protein RLP24

2

2

Small-scale

0.584

High

763135

NIP7
60S ribosome subunit biogenesis protein NIP7

2

2

Small-scale

0.584

High

763137

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.584

High

763114

PUF6
Pumilio homology domain family member 6

2

1

Small-scale

0.571

High

763107

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

2

2

High-throughput

0.565

High

763053

RRP14
Ribosomal RNA-processing protein 14

2

0

Small-scale

0.559

High

763076

NOP16
Nucleolar protein 16

2

0

Small-scale

0.559

High

763089

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

0

Small-scale

0.559

High

763124

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

513975

RL18B
Large ribosomal subunit protein eL18B

1

2

High-throughput

0.553

High

622916

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.536

High

721829

XPO1
Exportin-1

1

3

High-throughput

0.536

High

743176

PP12
Serine/threonine-protein phosphatase PP1-2

1

3

High-throughput

0.536

High

763059

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.536

High

763094

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

2

High-throughput

0.536

High

636460

ACE2
Metallothionein expression activator

1

4

High-throughput

0.515

High

746084

RAD5
DNA repair protein RAD5

1

3

High-throughput

0.515

High

763064

RFC5
Replication factor C subunit 5

1

2

High-throughput

0.515

High

603040

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.513

High

763081

FKH1
Fork head protein homolog 1

1

0

High-throughput

0.513

High

440837

KIN28
Serine/threonine-protein kinase KIN28

1

3

High-throughput

0.501

High

763054

SET3
SET domain-containing protein 3

1

0

High-throughput

0.493

High

763082

YRB2
Ran-specific GTPase-activating protein 2

1

0

High-throughput

0.493

High

763090

BPL1
Biotin--protein ligase

1

0

High-throughput

0.493

High

763091

ROM2
RHO1 GDP-GTP exchange protein 2

1

0

High-throughput

0.493

High

763092

ALAT2
Inactive alanine aminotransferase

1

0

High-throughput

0.493

High

763116

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.493

High

763123

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.493

High

382013

H4
Histone H4

1

2

High-throughput

0.479

High

383286

RL28
Large ribosomal subunit protein uL15

1

1

Small-scale

0.479

High

410045

RL25
Large ribosomal subunit protein uL23

1

1

Small-scale

0.479

High

433178

RL17A
Large ribosomal subunit protein uL22A

1

1

Small-scale

0.479

High

512360

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

569750

RL30
Large ribosomal subunit protein eL30

1

1

Small-scale

0.479

High

674532

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

677184

SPB1
27S pre-rRNA

1

3

High-throughput

0.479

High

677340

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

684679

RL5
Large ribosomal subunit protein uL18

1

1

Small-scale

0.479

High

694521

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

744277

CHD1
Chromo domain-containing protein 1

1

6

High-throughput

0.479

High

750055

MRT4
Ribosome assembly factor MRT4

1

2

High-throughput

0.479

High

758195

URB1
Nucleolar pre-ribosomal-associated protein 1

1

1

Small-scale

0.479

High

763057

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

763061

MAK5
ATP-dependent RNA helicase MAK5

1

11

High-throughput

0.479

High

763065

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

763070

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.479

High

763077

NUG1
Nuclear GTP-binding protein NUG1

1

4

High-throughput

0.479

High

763083

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

763088

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

763098

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.479

High

763099

NOP13
Nucleolar protein 13

1

2

High-throughput

0.479

High

763101

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

763102

RCM1
25S rRNA

1

5

High-throughput

0.479

High

763104

H3
Histone H3

1

4

High-throughput

0.479

High

763108

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

763111

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

763112

RRB1
Ribosome assembly protein RRB1

1

3

High-throughput

0.479

High

763115

UTP14
U3 small nucleolar RNA-associated protein 14

1

2

High-throughput

0.479

High

763120

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.479

High

763121

JIP5
WD repeat-containing protein JIP5

1

2

High-throughput

0.479

High

763122

DBP9
ATP-dependent RNA helicase DBP9

1

6

High-throughput

0.479

High

763125

NOC4
Nucleolar complex protein 4

1

6

High-throughput

0.479

High

763127

NOC3
Nucleolar complex-associated protein 3

1

4

High-throughput

0.479

High

763129

NOP12
Nucleolar protein 12

1

8

High-throughput

0.479

High

763131

REXO4
RNA exonuclease 4

1

4

High-throughput

0.479

High

763134

RRS1
Regulator of ribosome biosynthesis

1

2

High-throughput

0.479

High

763140

SSF2
Ribosome biogenesis protein SSF2

1

3

High-throughput

0.479

High

763143

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

597427

EF3A
Elongation factor 3A

1

2

High-throughput

0.470

High

381055

H2B1
Histone H2B.1

1

0

High-throughput

0.458

High

706722

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

734925

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

763063

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

763084

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

763103

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

763110

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

763119

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

763132

SGO1
Shugoshin

1

0

High-throughput

0.458

High

763138

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

763141

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

526346

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

544389

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

763080

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

763072

CIN4
GTP-binding protein CIN4

1

1

Small-scale

0.439

High

502963

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

503775

RL27A
Large ribosomal subunit protein eL27A

1

1

Small-scale

0.437

High

753285

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

763058

RL32
Large ribosomal subunit protein eL32

1

1

Small-scale

0.437

High

763074

ERP2
Protein ERP2

2

0

High-throughput

0.324

High

763105

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

2

0

High-throughput

0.322

High

763071

TCPD
T-complex protein 1 subunit delta

2

0

High-throughput

0.307

High

763133

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.279

Low

676796

BUD3
Bud site selection protein 3

1

0

High-throughput

0.269

Low

732870

GLPK
Glycerol kinase

1

0

High-throughput

0.269

Low

745426

GYP6
GTPase-activating protein GYP6

1

0

High-throughput

0.269

Low

763060

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

0

High-throughput

0.269

Low

763079

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.269

Low

763087

ETFB
Probable electron transfer flavoprotein subunit beta

1

0

High-throughput

0.269

Low

763096

ART5
Arrestin-related trafficking adapter 5

1

0

High-throughput

0.269

Low

763139

DAP1
Damage response protein 1

1

0

High-throughput

0.269

Low

738021

MKK1
MAP kinase kinase MKK1/SSP32

1

0

High-throughput

0.261

Low

763093

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

558670

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

763062

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

763066

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

763073

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

763113

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

763126

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025