HitPredict

Interactor 1: GRAP (Q08012)
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)
Gene: drk

Interactor 2: Q9V3V3 (Q9V3V3)
Pez, isoform A (Pez, isoform B) (Protein tyrosine phosphatase Pez)
Gene: Pez

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	22028469, 22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Dm			1 1252
+	Mm
		804959 GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08		MERL_MOUSE (1-450): 4.69e-130: 413: 18.22
+	Hs
		547001 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		EZRI_HUMAN (17-437): 4.35e-120: 387: 16.59
+	Hs
		663972 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PTN4_HUMAN (732-1247): 1.93e-112: 376: 17.73
+	Hs
		665853 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PTN6_HUMAN (961-1250): 2.28e-107: 352: 22.01
+	Mm
		574006 GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08		PTPRA_MOUSE (965-1246): 2.91e-93: 320: 21.72
+	Hs
		577009 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PTPRA_HUMAN (965-1246): 2.49e-93: 320: 21.72
+	Hs
		782792 CSK_HUMAN (2-136): 3.18e-25: 103: 36.30		PTPRO_HUMAN (222-1251): 7.29e-117: 395: 13.24
+	Hs
		617047 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PTPRE_HUMAN (1000-1246): 2.32e-84: 292: 21.24
+	Hs
		337601 ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43		E41L3_HUMAN (14-375): 2.27e-111: 377: 24.04
+	Hs
		337358 ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43		PTN4_HUMAN (732-1247): 1.93e-112: 376: 17.73
+	Hs
		557617 NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35		PTN4_HUMAN (732-1247): 1.93e-112: 376: 17.73
+	Hs
		663965 CRK_HUMAN (48-209): 9e-20: 87: 29.69		PTN4_HUMAN (732-1247): 1.93e-112: 376: 17.73
+	Hs
		337361 ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43		PTN6_HUMAN (961-1250): 2.28e-107: 352: 22.01
+	Mm
		420374 GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08		PTPRC_MOUSE (953-1249): 3.03e-63: 238: 21.74
+	Hs
		146925 GRB2_HUMAN (1-210): 1.39e-64: 200: 62.62		PTPRT_HUMAN (957-1248): 7.23e-59: 225: 21.60
+	Hs
		576998 CRK_HUMAN (48-209): 9e-20: 87: 29.69		PTPRA_HUMAN (965-1246): 2.49e-93: 320: 21.72
+	Hs
		782790 CSK_HUMAN (2-136): 3.18e-25: 103: 36.30		PTPRK_HUMAN (957-1249): 2.44e-54: 210: 19.87
+	Hs
		617158 CSK_HUMAN (2-136): 3.18e-25: 103: 36.30		PTPRZ_HUMAN (990-1250): 2.1e-44: 179: 17.58
+	Hs
		617084 CSK_HUMAN (2-136): 3.18e-25: 103: 36.30		PTPRG_HUMAN (999-1250): 2.4e-43: 174: 18.42
+	Dm
		337643 ABL_DROME (4-180): 1.03e-39: 146: 32.24		PTP69_DROME (976-1243): 1.35e-19: 97.8: 27.97