HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: ZFHX3 (Q15911)
Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)
Gene: ZFHX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 3703
+	Hs
		980760 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		ZFHX3_HUMAN (1-3703): 0: 1661: 100.00
+	Hs
		839732 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		LHX2_HUMAN (2591-2784): 3.55e-17: 89.3: 22.68
+	Hs
		980622 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		LHX8_HUMAN (2087-2232): 2.91e-16: 85.4: 24.66
+	Hs
		980912 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		LHX6_HUMAN (2087-2219): 5.5e-11: 69.6: 24.81
+	Hs
		839735 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		LHX2_HUMAN (2591-2784): 3.55e-17: 89.3: 22.68