Protein: IGSF3
Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)

Gene: IGSF3
Organism: Homo sapiens
Interactions: 82
UniProt ID: O75054

Gene Ontology (top 5):
GO:0009986 - cell surface
GO:0016020 - membrane
GO:0032808 - lacrimal gland development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

125101

LEG9
Galectin-9

3

12

High-throughput

0.770

High

269821

RASK
GTPase KRas

2

18

High-throughput

0.754

High

269828

LEG1
Galectin-1

2

12

High-throughput

0.694

High

269836

CEAM8
Cell adhesion molecule CEACAM8

1

17

High-throughput

0.691

High

269874

AMGO1
Amphoterin-induced protein 1

1

8

High-throughput

0.691

High

269884

TMPSD
Transmembrane protease serine 13

1

5

High-throughput

0.691

High

269853

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.675

High

269855

RAN
GTP-binding nuclear protein Ran

1

10

High-throughput

0.665

High

124994

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.656

High

269868

NADL2
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

3

0

High-throughput

0.638

High

269878

SPP2B
Signal peptide peptidase-like 2B

3

0

High-throughput

0.634

High

269835

CD9
CD9 antigen

1

20

High-throughput

0.625

High

269839

GPV
Platelet glycoprotein V

1

3

High-throughput

0.618

High

269852

ACTA
Actin, aortic smooth muscle

1

5

High-throughput

0.618

High

269892

ST14
Suppressor of tumorigenicity 14 protein

1

5

High-throughput

0.618

High

269822

LDLR
Low-density lipoprotein receptor

1

2

High-throughput

0.618

High

269824

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

5

High-throughput

0.618

High

269825

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.618

High

269838

BASI
Basigin

1

18

High-throughput

0.618

High

269847

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

269856

RAC1
Ras-related C3 botulinum toxin substrate 1

1

19

High-throughput

0.618

High

269885

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.618

High

269844

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.595

High

269867

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.595

High

269889

FBX6
F-box only protein 6

3

10

High-throughput

0.593

High

269872

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.578

High

269875

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.578

High

254670

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.575

High

269820

TSN15
Tetraspanin-15

1

20

High-throughput

0.575

High

269834

LEG3
Galectin-3

1

12

High-throughput

0.575

High

269864

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.575

High

269877

TSN14
Tetraspanin-14

1

20

High-throughput

0.575

High

269882

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.575

High

126395

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.553

High

137880

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.553

High

154452

CLD4
Claudin-4

1

1

Small-scale

0.553

High

269831

RAC2
Ras-related C3 botulinum toxin substrate 2

1

15

High-throughput

0.553

High

269833

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

269840

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.553

High

269841

LEG7
Galectin-7

1

12

High-throughput

0.553

High

269842

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.553

High

269846

RAC3
Ras-related C3 botulinum toxin substrate 3

1

18

High-throughput

0.553

High

269848

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.553

High

269849

RHOA
Transforming protein RhoA

1

19

High-throughput

0.553

High

269859

RHOG
Rho-related GTP-binding protein RhoG

1

16

High-throughput

0.553

High

269865

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.553

High

269866

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.553

High

269871

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.553

High

269887

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

269888

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.553

High

269891

FBX2
F-box only protein 2

2

10

High-throughput

0.549

High

269880

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.546

High

269826

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

2

High-throughput

0.536

High

269837

CTNB1
Catenin beta-1

1

4

High-throughput

0.536

High

269873

KTN1
Kinectin

1

7

High-throughput

0.536

High

269854

H4
Histone H4

1

2

High-throughput

0.515

High

269850

TSN5
Tetraspanin-5

1

20

High-throughput

0.514

High

269857

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

269829

CGB3
Choriogonadotropin subunit beta 3

1

0

High-throughput

0.481

High

269823

GCR
Glucocorticoid receptor

1

9

High-throughput

0.479

High

269830

MPRI
Cation-independent mannose-6-phosphate receptor

1

3

High-throughput

0.479

High

269851

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

269862

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

269832

H12
Histone H1.2

1

9

High-throughput

0.470

High

269860

VIGLN
Vigilin

1

9

High-throughput

0.470

High

217599

TGON2
Trans-Golgi network integral membrane protein 2

1

13

High-throughput

0.437

High

269827

LYN
Tyrosine-protein kinase Lyn

1

4

High-throughput

0.437

High

269843

ARL4C
ADP-ribosylation factor-like protein 4C

1

14

High-throughput

0.437

High

269858

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

269869

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

269876

ARL14
ADP-ribosylation factor-like protein 14

1

7

High-throughput

0.437

High

269879

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

269886

GAN
Gigaxonin

1

2

High-throughput

0.437

High

170577

CLGN
Calmegin

1

5

High-throughput

0.407

High

269870

S39A5
Zinc transporter ZIP5

1

2

High-throughput

0.407

High

269861

CDR2
Cerebellar degeneration-related protein 2

3

0

High-throughput

0.345

High

269845

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.328

High

269819

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

269863

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.279

Low

269883

MYADM
Myeloid-associated differentiation marker

1

0

High-throughput

0.279

Low

269890

PICK1
PRKCA-binding protein

1

0

High-throughput

0.279

Low

269881

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025